Some Good CMT Research News

[Guest guest]

Update on the Star Initiative from the CMTA.

The NIH completed the high-throughput screening program. Working with

a chemical library of more than 350,000 compounds, the NIH screened

each compound at approximately 7 different dosage levels – resulting

in more than 2 million unique screens.

Out of the 4000 FDA approved drugs, 10 " hits " or candidate medicines

were found. At this point in time, we are not able to divulge the names of these

compounds.

Out of the non-FDA approved drugs, 800 " hits " were discovered.

These 800 hits proved to reduce the amount of PMP 22 in the cells,

without causing any damage to the cells .

A second cell assay, created by Svaren, is being sent to the NIH

this week. The 810 hits discovered from the initial screening will be

tested on Svaren's new assay over the summer and the final results

should be released by the end of August.

At this point, we will know more about when the animal model testing

will occur.

We are extremely hopeful excited about the progress made by the

scientists involved in the STAR program. Never before has such a large

portfolio of over 800 compounds been tested on a cell line in this

fashion.