Re: CMT 1A and CIDP: Coexistence of two chronic neuropathies in a young child: Charc

[Guest guest]

Exactly how did these researchers diagnose these two different diseases?

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> Muscle Nerve. 2010 Oct;42(4):598-600.

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> Coexistence of two chronic neuropathies in a young child: Charcot-marie-tooth

disease type 1A and chronic inflammatory demyelinating polyneuropathy.

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> Marques W Jr, Funayama CA, Secchin JB, Lourenço CM, Gouvêa SP, Marques VD,

Bastos PG, Barreira AA.

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> Department of Neurosciences and Behavior Sciences, School of Medicine of

Ribeirão Preto, University of São o, SP 14049-900, Brazil.

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> Abstract

> We report an 18-month-old Charcot-Marie-Tooth type 1A (CMT1A) patient who

developed a rapid-onset neuropathy, with proximal and distal weakness, and

non-uniform nerve conduction studies. The neuropathy responded well to

immunomodulation, confirming the coexistence of an inherited and an inflammatory

neuropathy. Unexpected clinical and/or electrophysiological manifestations in

CMT1A patients should alert clinicians to concomitant inflammatory neuropathy.

In addition, this association raises reflections about disease mechanism in

CMT1A.

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