Canine inherited motor + sensory neuropathies: An updated classification in 22

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Vet J. 2010 Jul 15.

Canine inherited motor and sensory neuropathies: An updated classification in 22

breeds and comparison to Charcot-Marie-Tooth disease.

Granger N.

Department of Veterinary Medicine, University of Cambridge, Madingley Road,

Cambridge, CB3 0ES, United Kingdom.

Abstract

Canine inherited neuropathies form a group of degenerative diseases affecting

motor and/or sensory and autonomic peripheral nerves. There is now a large

number of inherited motor and sensory neuropathies (IMSN) reported in the

veterinary literature, for which clinical, electrophysiological,

histopathological and mode of inheritance data are available.

Their resemblance with Charcot-Marie-Tooth disease in humans is suggested,

although direct comparison is difficult due to the small number of cases

described in each breed and the lack of genetic knowledge in dogs.

Charcot-Marie-Tooth disease forms a wide group of hereditary neuropathies for

which a genetic mutation is recognised in more than 70% of patients.

In dogs, no genetic mutation has so far been identified and the knowledge

available for human hereditary neuropathies may be useful to identify genetic

mutations in dogs. This review provides an update on data available on inherited

neuropathy in Leonberger dogs and three new degenerative neuropathies are

briefly described in two Russian Black terriers, two Cocker Spaniels and a

Podhale Shepherd dog.