IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive musc

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Muscle Nerve. 2010 Jul 21.

IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive

muscle atrophy.

Kawagashira Y, Kondo N, Atsuta N, Iijima M, Koike H, Katsuno M, Tanaka F,

Kusunoki S, Sobue G.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya

466-8550, Japan.

Abstract

We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy,

predominantly exhibiting severe motor symptoms, accompanied by extensive muscle

atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed

mild retardation of motor conduction velocities and significant prolongation of

distal latency. Sural nerve biopsy revealed widely spaced myelin and positive

staining of myelinated fibers with an IgM antibody. Predominant motor symptoms

with muscle atrophy can be one of the clinical manifestations of anti-MAG

neuropathy.