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CMT 1A patients with low level of impairment have a higher energy cost of walkin

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Neuromuscular Disorders Volume 21, Issue 1, Pages 52-57 (January 2011)

Charcot-Marie-Tooth 1A patients with low level of impairment have a higher

energy cost of walking than healthy individuals

Federica Menottia, Francesco Felicia, Antonello Damianib, Fortunato Mangiolab,

o Vannicellib, Macalusoa

Abstract

The study aimed at quantifying the walking energy cost of a group of

Charcot-Marie-Tooth 1A patients (CMT1A), with low severity of walking

impairment, in comparison with healthy individuals.

Oxygen uptake was measured in 8 patients (age-range 20–48years; Barthel >90;

Tinetti >20) and 8 healthy individuals, matched for age and gender, when walking

on a circuit for 5-min at their self-selected speeds ( " slow " , " comfortable " and

" fast " ).

Both comfortable and fast speeds were lower in patients than in the control

group (0.92±0.16 vs 1.16±0.22 and 1.27±0.27 vs 1.61±0.22ms & #8722;1,

respectively; P<0.05), whereas walking energy cost per unit of distance was

higher in patients than in the control group (P<0.05) at both " comfortable "

(2.27±0.35 vs 1.92±0.21Jkg & #8722;1m & #8722;1) and " fast " speed (3.05±0.35 vs

2.37±0.42Jkg & #8722;1m & #8722;1).

CMT1A patients, therefore, choose to walk slower but with higher metabolic cost

compared to healthy individuals, despite no clinically evident walking

impairment, which is likely due to altered walking patterns.

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