Update on Charcot-Marie-Tooth Disease.

[Guest guest]

Update on Charcot-Marie-Tooth Disease.

Curr Neurol Neurosci Rep. 2010 Nov 16

Patzkó A, Shy ME.

Wayne State University, 421 East Canfield, Elliman Building 3209, Detroit, MI,

48201, USA.

Abstract

Charcot-Marie-Tooth disease (CMT) disease encompasses a genetically

heterogeneous group of inherited neuropathies, also known as hereditary motor

and sensory neuropathies. CMT results from mutations in more than 40 genes

expressed in Schwann cells and neurons causing overlapping phenotypes. The

classic CMT phenotype reflects length-dependent axonal degeneration

characterized by distal sensory loss and weakness, deep tendon reflex

abnormalities, and skeletal deformities.

Recent articles have provided insight into the molecular pathogenesis of CMT,

which, for the first time, suggest potential therapeutic targets. Although there

are currently no effective medications for CMT, multiple clinical trials are

ongoing or being planned. This review will focus on the underlying

pathomechanisms and diagnostic approaches of CMT and discuss the emerging

therapeutic strategies.

[Guest guest]

This morning I posted the Abstract. Now the entire article has been uploaded

into our File titled " Future of Medical Research " .

[Guest guest]

Thank you!  It should be interesting to read...when I have a chance! :-)

 

Mother to Ashlee Rayne & Aimee Renae

________________________________

From: " -owner " <-owner >

Sent: Wed, November 17, 2010 6:54:38 PM

Subject: Re: Update on Charcot-Marie-Tooth Disease.

 

This morning I posted the Abstract. Now the entire article has been uploaded

into our File titled " Future of Medical Research " .