CMT 1A and CIDP: Coexistence of two chronic neuropathies in a young child: Charc

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Muscle Nerve. 2010 Oct;42(4):598-600.

Coexistence of two chronic neuropathies in a young child: Charcot-marie-tooth

disease type 1A and chronic inflammatory demyelinating polyneuropathy.

Marques W Jr, Funayama CA, Secchin JB, Lourenço CM, Gouvêa SP, Marques VD,

Bastos PG, Barreira AA.

Department of Neurosciences and Behavior Sciences, School of Medicine of

Ribeirão Preto, University of São o, SP 14049-900, Brazil.

Abstract

We report an 18-month-old Charcot-Marie-Tooth type 1A (CMT1A) patient who

developed a rapid-onset neuropathy, with proximal and distal weakness, and

non-uniform nerve conduction studies. The neuropathy responded well to

immunomodulation, confirming the coexistence of an inherited and an inflammatory

neuropathy. Unexpected clinical and/or electrophysiological manifestations in

CMT1A patients should alert clinicians to concomitant inflammatory neuropathy.

In addition, this association raises reflections about disease mechanism in

CMT1A.