Collagen XXVIII is a distinctive component of the peripheral nervous system node

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Glia. 2010 Sep 9

Collagen XXVIII is a distinctive component of the peripheral nervous system

nodes of ranvier and surrounds nonmyelinating glial cells.

Grimal S, Puech S, Wagener R, Ventéo S, Carroll P, Fichard-Carroll A.

INSERM U583, Institut des Neurosciences de Montpellier, Université Montpellier

II Hôpital Saint Eloi, 80 rue Augustin Fliche, BP 74103, 34091 Montpellier Cedex

5.

Abstract

Growing evidence indicates that collagens perform crucial functions during the

development and organization of the nervous system. Collagen XXVIII is a

recently discovered collagen almost exclusively expressed in the peripheral

nervous system (PNS).

In this study, we show that this collagen is associated with nonmyelinated

regions of the PNS. With the notable exception of type II terminal Schwann cell

in the hairy skin, collagen XXVIII surrounds all nonmyelinating glial cells

studied.

This includes satellite glial cells of the dorsal root ganglia, terminal Schwann

cells type I around mechanoceptors in the skin, terminal Schwann cells around

proprioceptors in the muscle spindle or at the neuromuscular junction and

olfactory ensheathing cells.

Collagen XXVIII is also detected at nodes of Ranvier where the myelin sheath of

myelinated fibers is interrupted and is thus a distinctive component of the PNS

nodal gap.

The correlation between the absence of myelin and the presence of collagen

XXVIII is confirmed in a mouse model of Charcot-Marie-Tooth characterized by

dysmyelinated nerve fibers, in which enhancement of collagen XXVIII labeling is

observed.