(mentions CMT) Describing the hexapeptide identity platform between the influenz

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Describing the hexapeptide identity platform between the influenza A H5N1 and

Homo sapiens proteomes.

Kanduc D.

Department of Biochemistry and Molecular Biology, University of Bari, Italy.

Abstract

We searched the primary sequence of influenza A H5N1 polyprotein for hexamer

amino acid sequences shared with human proteins using the Protein International

Resource database and the exact peptide matching analysis program. We find that

the viral polyprotein shares numerous hexapeptides with the human proteome.

The human proteins involved in the viral overlap are represented by antigens

associated with basic cell functions such as proliferation, development, and

differentiation.

Of special importance, many human proteins that share peptide sequences with

influenza A polyprotein are antigens such as reelin, neurexin I- & #945;,

myosin-IXa, Bardet-Biedl syndrome 10 protein, syndrome transcription

factor, disrupted in schizophrenia 1 protein, amyotrophic lateral sclerosis 2

chromosomal region candidate gene 17 protein, fragile X mental retardation 2

protein, and jouberin. That is, the viral-vs-human overlap involves human

proteins that, when altered, have been reported to be potentially associated

with multiple neurological disorders that can include autism, epilepsy, obesity,

dystonia, ataxia-telangiectasia, amyotrophic lateral sclerosis, sensorineural

deafness, sudden infant death syndrome, Charcot-Marie-Tooth disease, and

myelination.

The present data are discussed as a possible molecular basis for understanding

influenza A viral escape from immunosurveillance and for defining anti-influenza

immune-therapeutic approaches devoid of collateral adverse events.