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Re: B6 from Dr. Parry

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Some of the newcomers may not be aware of the B6 issue and CMT, so here's a few

words from Dr. Parry from our Files.

Vitamin B6 Use: Current as of 11/11/2004 – by Gareth J. Parry, M.D.

The RDA (recommended daily allowance) of vitamin B6 is 2 mg and the MDR (minimum

daily requirement is 0.1-0.2 mg). The amount in a typical multivitamin is 5 mg

although many have 10 mg and, obviously, some have 8 mg. There are several

products available over the counter that contain 20 mg.

All the research that has been done indicates that all of these doses are safe

for normal people and I am not concerned for my CMT patients at these doses.

Larger dose tablets can be found - there used to be a 500 mg tablet!

In our studies, the lowest dose that we found to be definitely toxic to nerves

was 500 mg daily; we had one patient who was adamant that she was taking only

200 mg daily who developed nerve damage although she was also taking a lot of

B6-rich foods. One doctor in London, England claims that 50 mg daily can be

toxic to the nerves but no one else has been able to show that.

In summary, I tell my patients under no circumstances should they take more than

20 mg daily and I prefer them to take no more than 10 mg daily. 8 mg daily is

certainly safe.

Gareth J. Parry, MD

Department of Neurology

University of Minnesota

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