Stem cell study could aid motor neurone disease research

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Stem cell study could aid motor neurone disease research

http://www.eurekalert.org/pub_releases/2011-03/uoe-scs030111.php

Scientists have discovered a new way to generate human motor nerve cells in a

development that will help research into motor neurone disease

Scientists have discovered a new way to generate human motor nerve cells in a

development that will help research into motor neurone disease.

A team from the Universities of Edinburgh, Cambridge and Cardiff has created a

range of motor neurons – nerves cells that send messages from the brain and

spine to other parts of the body – from human embryonic stem cells in the

laboratory.

It is the first time that researchers have been able to generate a variety of

human motor neurons, which differ in their make-up and display properties

depending on where they are located in the spinal cord.

The research, published in the journal Nature Communications, could help

scientists better understand motor neurone disease. The process will enable

scientists to create different types of motor neurons and study why some are

more vulnerable to disease than others.

Motor neurons control muscle activity such as speaking, walking, swallowing and

breathing. However, in motor neurone disease – a progressive and ultimately

fatal disorder – these cells break down leading to paralysis, difficulty

speaking, breathing and swallowing.

Previously scientists had only been able to generate one particular kind of

motor neuron, which they did by using retinoic acid, a vitamin A derivative.

In the latest study, scientists have found a way to generate a wider range of

motor neurons using a new process without retinoic acid.

Professor Siddharthan Chandran, Director of the Euan Mac Centre for Motor

Neurone Disease Research at the University of Edinburgh, said: " Motor neurons

differ in their make-up, so understanding why some are more vulnerable than

others to disease is important for developing treatment for this devastating

condition. "

Dr Rickie Patani, of the University of Cambridge, said: " Although motor neurons

are often considered as a single group, they represent a diverse collection of

neuronal subtypes. The ability to create a range of different motor neurons is a

key step in understanding the basis of selective subtype vulnerability in

conditions such as motor neuron disease and spinal muscular atrophy. "

Scientists have discovered a new way to generate human motor nerve cells in a

development that will help research into motor neurone disease

Scientists have discovered a new way to generate human motor nerve cells in a

development that will help research into motor neurone disease.

A team from the Universities of Edinburgh, Cambridge and Cardiff has created a

range of motor neurons – nerves cells that send messages from the brain and

spine to other parts of the body – from human embryonic stem cells in the

laboratory.

It is the first time that researchers have been able to generate a variety of

human motor neurons, which differ in their make-up and display properties

depending on where they are located in the spinal cord.

The research, published in the journal Nature Communications, could help

scientists better understand motor neurone disease. The process will enable

scientists to create different types of motor neurons and study why some are

more vulnerable to disease than others.

Motor neurons control muscle activity such as speaking, walking, swallowing and

breathing. However, in motor neurone disease – a progressive and ultimately

fatal disorder – these cells break down leading to paralysis, difficulty

speaking, breathing and swallowing.

Previously scientists had only been able to generate one particular kind of

motor neuron, which they did by using retinoic acid, a vitamin A derivative.

In the latest study, scientists have found a way to generate a wider range of

motor neurons using a new process without retinoic acid.

Professor Siddharthan Chandran, Director of the Euan Mac Centre for Motor

Neurone Disease Research at the University of Edinburgh, said: " Motor neurons

differ in their make-up, so understanding why some are more vulnerable than

others to disease is important for developing treatment for this devastating

condition. "

Dr Rickie Patani, of the University of Cambridge, said: " Although motor neurons

are often considered as a single group, they represent a diverse collection of

neuronal subtypes. The ability to create a range of different motor neurons is a

key step in understanding the basis of selective subtype vulnerability in

conditions such as motor neuron disease and spinal muscular atrophy. "