Re:Does anybody have another source for this information

[Guest guest]

Hi ,

Here's the Abstract. It is also most likely in our 2010 Archives. I can't

remember if I had the full text or only the Abstract. If you can't find the full

text, try contacting Dr. Suter at the Institute.

Gretchen

Science. 2010 Jun 11;328(5984):1415-8. Epub 2010 May 6.

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral

nerve overmyelination.

Cotter L, Ozçelik M, C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter

U, Tricaud N.

Institute of Cell Biology, Department of Biology, Eidgenössische Technische

Hochschule (ETH) Zürich, CH-8093 Zürich, Switzerland.

Abstract

The thickness of the myelin sheath that insulates axons is fitted for optimal

nerve conduction velocity. Here, we show that, in Schwann cells, mammalian disks

large homolog 1 (Dlg1) interacts with PTEN (phosphatase and tensin homolog

deleted on chromosome 10) to inhibit axonal stimulation of myelination. This

mechanism limits myelin sheath thickness and prevents overmyelination in mouse

sciatic nerves. Removing this brake results also in myelin outfoldings and

demyelination, characteristics of some peripheral neuropathies. Indeed, the Dlg1

brake is no longer functional in a mouse model of Charcot-Marie-Tooth disease.

Therefore, negative regulation of myelination appears to be essential for

optimization of nerve conduction velocity and myelin maintenance.