RESEARCH - Decreased density of serotonin 5-HT2A receptors in RA

[Guest guest]

Ann Rheum Dis. 2006 Jun;65(6):816-9.

Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis.

Kling A, Rantapaa-Dahlqvist S, Stenlund H, Mjorndal T.

Division of Clinical Pharmacology, Umea University Hospital, S-901 85 Umea,

Sweden. anders.kling@....

BACKGROUND: Animal studies have indicated that 5-HT2(A) receptors could play

a role in arthritic diseases. OBJECTIVE: To analyse the binding properties

of 5-HT2(A) receptors in patients with rheumatoid arthritis. METHODS: Using

a radioactive binding assay, 43 patients with rheumatoid arthritis were

compared with 49 sex and age matched controls for density and affinity

(measured as B(max) and K(d)) of 5-HT2(A) serotonin receptors. Genotyping,

using polymerase chain reaction, was undertaken to exclude the possibility

that differences in the genetic polymorphism T102C for the 5-HT2(A) receptor

determine differences in receptor density. RESULTS: Mean of B(max) of

5-HT2(A) receptors in rheumatoid patients was significantly lower than in

controls, at 45.3 v 57.4 fmol/mg protein (p = 0.004), but there was no

significant difference in K(d). The T102C receptor polymorphism genotypes

showed a skewed distribution between the two groups. Even when adjusted for

this, there was a significant difference in B(max) between the groups.

CONCLUSIONS: The density of 5-HT2(A) serotonin receptors in patients with

rheumatoid arthritis is markedly reduced. This could either reflect a

difference involved in the susceptibility to the disease or be a secondary

effect of the disease.

PMID: 16699051

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6699051

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org