RESEARCH - Increased risk of additional lymphoma types in those with untreated celiac disease

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Increased Risk of Additional Lymphoma Types in those with Untreated

Celiac Disease

Gut 2005;54:54-59.

Celiac.com 01/20/2005 - A link between untreated celiac disease

and a rare enteropathy-type T-cell lymphoma (ETTL) has been well established

by several studies. According to Dr. Karin Ekstrom Smedby of the Karolinska

Institute in Stockholm and colleagues, there is also an increase in the

prevalence of other types of lymphomas in those with celiac disease, such as

B cell and non-intestinal lymphomas. In their study the researchers reviewed

and reclassified 56 cases of malignant lymphomas that occurred in 11,650

hospitalized celiac disease patients in Sweden. The observed numbers of

lymphoma subtypes were compared with those expected in the Swedish

population. The researchers discovered that a majority of the lymphomas were

not intestinal T-cell lymphomas, but were B-cell non-Hodgkin lymphoma (NHL).

In addition, 44% of the patients with B cell NHL had a history of other

autoimmune/inflammatory diseases. As expected, the relative risks for T-cell

NHL and primary gastrointestinal lymphomas were markedly increased.

According to the researchers: " Most lymphomas complicating coeliac disease

are indeed related to the disease and are not of the ETTL-type. There was a

remarkable aggregation of autoimmune/inflammatory disorders, female sex,

coeliac disease, and B cell lymphoma. "

http://www.celiac.com/st_prod.html?p_prodid=1087

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