RESEARCH - IFN-related and other immune genes are downregulated in PBLs in the menstrual cycle

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J Clin Endocrinol Metab. 2004 May;89(5):2501-4.

Interferon-related and other immune genes are downregulated in peripheral

blood leukocytes in the luteal phase of the menstrual cycle.

Dosiou C, Lathi RB, Tulac S, Huang ST, Giudice LC.

Department of Medicine, Stanford University Medical Center, Stanford, CA

94305, USA.

Interaction between the endocrine and the immune systems has been suggested

by observations of sexual dimorphism of the immune response, differential

susceptibility to autoimmunity between the sexes, changes in autoimmune

disease activity during the menstrual cycle and in pregnancy and in vitro

studies of hormonal influence on cytokine production.We hypothesized that if

there is hormonal regulation of the immune response, this would be manifest

in peripheral blood leukocytes (PBLs) at different phases of the menstrual

cycle. In this study, we describe gene profiling of PBLs from the follicular

and luteal phases of the menstrual cycle. We observe important differences

in immune gene expression, with significant down-regulation of the Th1

immune response in the luteal phase. A significant number of interferon

(IFN)-related genes are amongst the downregulated genes. These results

support significant hormonal regulation of the immune system and may have

therapeutic implications in diseases of autoimmunity in women.

PMID: 15126584

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15126584

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http://jcem.endojournals.org/cgi/content/full/89/5/2501

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