REVIEW - Malignancy and autoimmunity

[Guest guest]

Curr Opin Rheumatol. 2006 Mar;18(2):129-34.

Malignancy and autoimmunity.

Bernatsky S, Ramsey-Goldman R, e A.

aDivision of Clinical Epidemiology, Montreal General Hospital, Quebec,

Canada bDivision of Rheumatology, Northwestern University, Chicago,

Illinois, USA cDivision of Allergy and Immunology, Montreal General

Hospital, Quebec, Canada.

PURPOSE OF REVIEW: The association of cancer with autoimmune disease has

been under investigation for several years. Reports have appeared suggesting

increased cancer risk in autoimmune rheumatic diseases. Evidence has been

accumulating recently in rheumatoid arthritis, Sjogren's syndrome, systemic

lupus erythematosus, and scleroderma/systemic sclerosis. This review focuses

on recent publications regarding risk of cancer in these conditions. RECENT

FINDINGS: Despite a lack of a strong association between rheumatoid

arthritis and cancer overall, studies show an increased risk for the

development of lymphoma in rheumatoid arthritis. There are data suggesting

an increased risk for rheumatoid arthritis patients regarding lung cancer.

In Sjogren's syndrome-related malignancies, most publications in the past

year relate to non-Hodgkin's lymphomas, and suggest possible mechanisms

driving the association. Data substantiate an increased risk of certain

cancers in systemic lupus erythematosus; the risk appears to be most

heightened for lymphoma. A recent cohort study examined cancer risk in

scleroderma; the estimates were lower than previous studies had suggested,

and the confidence intervals relatively imprecise, making a definitive

conclusion difficult.

SUMMARY: There have been several papers published

related to cancer in the rheumatic diseases, particularly inflammatory

arthritis, Sjogren's syndrome, systemic lupus erythematosus, and

scleroderma/systemic sclerosis. Continuing interest in the association

between autoimmune rheumatic diseases and malignancy is likely, given the

potential impact in terms of understanding both rheumatic diseases and

cancer.

PMID: 16462517

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16462517 & itool=iconabstr & query_hl=6 & itool=pubmed_DocSum

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[Guest guest]

Thanks !

Jill

On 2/20/06, <Matsumura_Clan@...> wrote:

>

> Curr Opin Rheumatol. 2006 Mar;18(2):129-34.

>

>

> Malignancy and autoimmunity.

>

>

> Bernatsky S, Ramsey-Goldman R, e A.

>

> aDivision of Clinical Epidemiology, Montreal General Hospital, Quebec,

> Canada bDivision of Rheumatology, Northwestern University, Chicago,

> Illinois, USA cDivision of Allergy and Immunology, Montreal General

> Hospital, Quebec, Canada.

>

>

> PURPOSE OF REVIEW: The association of cancer with autoimmune disease has

> been under investigation for several years. Reports have appeared

> suggesting

> increased cancer risk in autoimmune rheumatic diseases. Evidence has been

> accumulating recently in rheumatoid arthritis, Sjogren's syndrome,

> systemic

> lupus erythematosus, and scleroderma/systemic sclerosis. This review

> focuses

> on recent publications regarding risk of cancer in these conditions.

> RECENT

> FINDINGS: Despite a lack of a strong association between rheumatoid

> arthritis and cancer overall, studies show an increased risk for the

> development of lymphoma in rheumatoid arthritis. There are data suggesting

> an increased risk for rheumatoid arthritis patients regarding lung cancer.

> In Sjogren's syndrome-related malignancies, most publications in the past

> year relate to non-Hodgkin's lymphomas, and suggest possible mechanisms

> driving the association. Data substantiate an increased risk of certain

> cancers in systemic lupus erythematosus; the risk appears to be most

> heightened for lymphoma. A recent cohort study examined cancer risk in

> scleroderma; the estimates were lower than previous studies had suggested,

> and the confidence intervals relatively imprecise, making a definitive

> conclusion difficult.

>

> SUMMARY: There have been several papers published

> related to cancer in the rheumatic diseases, particularly inflammatory

> arthritis, Sjogren's syndrome, systemic lupus erythematosus, and

> scleroderma/systemic sclerosis. Continuing interest in the association

> between autoimmune rheumatic diseases and malignancy is likely, given the

> potential impact in terms of understanding both rheumatic diseases and

> cancer.

>

> PMID: 16462517

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16462517 & itool=iconabstr & query_hl=6 & itool=pubmed_DocSum

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

>

>