Re: Effectiveness Loss?

[Guest guest]

Maybe she's just having flares? How do these days of pain coincide with

her injection days? When I used the 50 mg once-weekly Enbrel, I found

that it didn't seem to last the full week.

As for injection site reactions sometimes, I am the same way. I used

Enbrel for quite a time before I had the first reaction, but

periodically I get them. Mine are mild, about like a mosquito bite. My

rheumy didn't have an explanation for why I get a reaction once in a

while. She does let the Enbrel warm up a bit before injecting, doesn't

she?

Sue

On Monday, September 18, 2006, at 12:03 PM, nynypa wrote:

> In the middle of May, my 78-year-old Mother added Enbrel to her regimen

> of MTX and Medrol to treat her RA. Until about 3 weeks ago, it was

> working wonderfully. She was mercifully free of pain. About a month

> ago, she was able to begin a water exercise program and had, most

> importantly, been able to lower her dose of Medrol to 2 mg/day. She

> has been on Medrol for a year at varying doses. Sadly, within the past

> 3 weeks, she has begun to have joint pain - two days of intense joint

> pain, then reduction of pain for a couple of days, and then another

> 2-3-

> day flair. I wonder if perhaps Enbrel is losing its effectiveness for

> her. Another oddity, she had not had any injection site reactions

> until two weeks ago, and has now had them with both of her last two

> injections. Does this scenario sound familiar to anyone else, and, if

> so, what's the next step?

[Guest guest]

Your mother's flare could have been caused by the increased exercise or the

reduction of the medrol-or a combination of both and sometimes we flare for no

reason at all. Exercise is important but if she has not exercised in a while

she probably needs to go very slow and increase her activity gradually. When we

get to feeling better most of us have a tendency to overdo. Also since she has

not had a reaction before I would be interested in knowing if maybe this was a

newly refilled RX of enbrel. I had one refill that seemed to itch a little and

have not had that happen before and also for the 8 shots I had in that refill

they did not seem to be as effective. I wondered maybe if at some point they

had not been kept cold or if there was something a little different about that

refill???? With the next batch everthing was back as before-no itching and

better effectiveness.

nynypa <nynypa@...> wrote: In the middle of May, my 78-year-old

Mother added Enbrel to her regimen

of MTX and Medrol to treat her RA. Until about 3 weeks ago, it was

working wonderfully. She was mercifully free of pain. About a month

ago, she was able to begin a water exercise program and had, most

importantly, been able to lower her dose of Medrol to 2 mg/day. She

has been on Medrol for a year at varying doses. Sadly, within the past

3 weeks, she has begun to have joint pain - two days of intense joint

pain, then reduction of pain for a couple of days, and then another 2-3-

day flair. I wonder if perhaps Enbrel is losing its effectiveness for

her. Another oddity, she had not had any injection site reactions

until two weeks ago, and has now had them with both of her last two

injections. Does this scenario sound familiar to anyone else, and, if

so, what's the next step?

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