Linaclotide Re: Leaky gut -- new pathway found, novel drug in development

[Guest guest]

Why only IBS with constipation? DS has IBS with diarrhoea.

Patiencd

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> >

> > Stronger Intestinal Barrier May Prevent Cancer in the Rest of the

> Body, New

> > Study Suggests

> >

> > http://www.sciencedaily.com/releases/2012/02/120221212345.htm

> >

> > " It appears that the hormone receptor guanylyl cyclase C (GC-C) -- a

> > previously

> > identified tumor suppressor that exists in the intestinal tract --

> plays a

> > key

> > role in strengthening the body's intestinal barrier, which helps

> separate

> > the

> > gut world from the rest of the body, and possibly keeps cancer at bay.

> > Without

> > the receptor, that barrier weakens.

> > ...

> > ...silencing GC-C in mice compromised the integrity of the intestinal

> > barrier.

> > It allowed inflammation to occur and cancer-causing agents to seep out

> into

> > the

> > body, damaging DNA and forming cancer outside the intestine, including

> in

> > the

> > liver, lung and lymph nodes.

> >

> > Conversely, stimulating GC-C in intestines in mice strengthened the

> > intestinal

> > barrier opposing these pathological changes.

> > ...

> > A new drug containing GC-C is now on the verge of hitting the market,

> but

> > its

> > intended prescribed purpose is to treat constipation.

> >

> > This study helps lays the groundwork, Dr. Waldman said, for future

> > pre-clinical

> > and clinical studies investigating GC-C's abilities beyond those

> treatments

> > in

> > humans, including prevention and treatment of inflammatory bowel

> disease and

> > cancer.

> > ...

> > " Now, if you want to prevent inflammation or cancer in humans, then we

> need

> > to

> > start thinking about feeding people hormones that activate GC-C to

> tighten

> > up

> > the barrier. "

> >

> > Journal References:

> >

> > 1.Jieru Egeria Lin, Adam Eugene Snook, Peng Li, Arthur Stoecker,

> > Gilbert

> > Won Kim, Sullivan Magee, Vladimir Mejia ,

>

> > Valentino, Terry Hyslop, Schulz, Arthur Waldman.

> GUCY2C

> > Opposes

> > Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent

> Intestinal

> > Barrier

> > Integrity. PLoS ONE, 2012; 7 (2): e31686 DOI:

> 10.1371/journal.pone.0031686

> >

> > 2. A. Valentino, Jieru E. Lin, Adam E. Snook, Peng Li, Gilbert

> W.

> > Kim,

> > Glen Marszalowicz, S. Magee, Terry Hyslop, Schulz,

>

> > A.

> > Waldman. A uroguanylin-GUCY2C endocrine axis regulates feeding in

> mice.

> > Journal

> > of Clinical Investigation, 2011; 121 (9): 3578 DOI: 10.1172/JCI57925

> >

>