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The regression formula for predicting odds of having cirrhosis is as follows:

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Here's a site that can predict whether or not you have cirrhosis from lab test results. It works on mine.

SuZie

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http://www.haltctri al.org/cirrhosis .html

Our predictive model relies on a few standard laboratory values that are routinely available in patients with hepatitis C - platelet count, AST/ALT ratio and INR.

The regression formula for predicting odds of having cirrhosis is as follows:

log odds (predicting cirrhosis) = -5.56 - 0.0089 x platelet (x103/mm3) + 1.26 x AST/ALT ratio + 5.27 x INR. The formula to calculate predicted probability is exp(logodds) /(1+exp(logodds) ).

Our model performed well in the objective of predicting histological cirrhosis in our population of >1,100 well-characterized patients with chronic hepatitis C and advanced fibrosis. A cutoff predicted value of < 0.2 to exclude cirrhosis, would misclassify only 7.8% (24/309) of patients with cirrhosis (negative predictive value of 85%), while a cutoff predicted value of >0.5 to identify patients with cirrhosis, would misclassify 14.8% (70/474) of noncirrhotics (positive predictive value of 75%). Approximately half, 48.5%, of the patients fell between the two cutoff values and would not be classified accurately. A cutoff of 0.6 would lead to misclassification as cirrhotic in 8.0% (38/474) of noncirrhotics, but would increase the proportion of patients that would not be classifiable to 59.3%.

The ranges used in our analysis are as follows:

Platelets 39-442INR 0.8 - 1.6 AST 18 - 789ALT 15 - 772

Please enter the following 4 lab values then click Calculate/Recalcula te button:

Platelets (103/mm3)

Prothrombin Time International Normalized Ratio (PT/INR)

AST (U/L)

ALT (U/L)

Probability of Biopsy Demonstrating Cirrhosis

Tim Parsons knoxville,tn 37931

x107 work

www.knoxville1. com

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