Re: Re: Intestinal Bacteria Produce Neurotransmitt...

[Guest guest]

Not getting anything on google except other strains of Bifido but its human origin I think, would that mean fecal implants?

Mx

This is very interesting Natasa, thank you for posting it, i dont suppose there are any probiotics around that contain Bifidobacteriumdentium, does anyone know, Mandi......?N x>> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In> Inflammation> > Monday, June 18, 2012> > Source : American Society for Microbiology> > Researchers at Baylor College of Medicine and Texas Children's Hospital> have> identified commensal bacteria in the human intestine that produce a> neurotransmitter> that may play a role in preventing or treating inflammatory bowel> diseases such as> Crohn's disease.> > "We identified, to our knowledge, the first bifidobacterial strain,> Bifidobacterium> dentium, that is capable of secreting large amounts of> gamma-aminobutyric acid> (GABA). This molecule is a major inhibitory neurotransmitter in the> central and> enteric nervous systems," says Karina Pokusaeva, a researcher on the> study and a> member of the laboratory of Versalovic.> > GABA is one of the chief inhibitory neurotransmitters in the human> central nervous> system. It plays a role in regulating pain and some pain relieving drugs> currently> on the market act by targeting GABA receptors on neural cells.> > Pokusaeva and her colleagues were interested in understanding the role> the human> microbiome might play in pain and scanned the genomes of potentially> beneficial> intestinal microorganisms, identified by the Human Microbiome Project,> for evidence> of a gene that would allow them to create GABA.> > "Lab analysis of metagenomic DNA sequencing data allowed us to> demonstrate that> microbial glutamate decarboxylase encoding gene is very abundant in> intestinal> microbiota as compared to other body sites," says Pokusaeva. One of the> most> prolific producers of GABA was B. dentium, which appears to secrete the> compound to> help it survive the acid environment.> > In addition to its pain modulating properties, GABA may also be capable> of> inhibiting inflammation. Recent studies have shown that immune cells> called> macrophages also possess GABA receptors. When these receptors were> activated on the> macrophages there was a decrease in the production of compounds> responsible for> inflammation.> > "Our lab was curious to explore if GABA produced by intestinal human> isolate B.> dentium could have an effect on GABA receptors present in immune cells,"> says> Pokusaeva. Together with their collaborators Dr. Yamada and Dr.> Lacorazza they found> that when the cells were exposed to secretions from the bacteria, they> exhibited> increased expression of the GABAA receptor in the immune cells.> > While the findings are preliminary, they suggest the possibility that B.> dentium and> the compounds it secretes could play a role in reducing inflammation> associated with> inflammatory bowel diseases.> > The next step, says Pokusaeva is to conduct in vitro experiments to> determine if the> increased GABAA expression correlates with a decrease in production of> cytokines> associated with inflammation. GABAA receptor signaling may also> contribute to pain> signaling in the gut and may somehow be involved in abdominal pain> disorders.> > "Our preliminary findings suggest that Bifidobacterium dentium could> potentially> have an inhibitory role in inflammation; however more research has to be> performed> to further prove our hypothesis," says Pokusaeva>

[Guest guest]

Mmmm yeas, see bradstreet new post, it links in with recent article on good bacteria having bad effects on the gut and immune system if living in the wrong place (ie small intestine), so supplementing orally might not be the right answer … Reply-To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Date: Wed, 27 Jun 2012 06:11:26 -0400 (EDT)To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Subject: Re: Re: Intestinal Bacteria Produce Neurotransmitt...

Not getting anything on google except other strains of Bifido but its human origin I think, would that mean fecal implants?Mx

This is very interesting Natasa, thank you for posting it, i dont suppose there are any probiotics around that contain Bifidobacteriumdentium, does anyone know, Mandi......?N x>> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In> Inflammation> > Monday, June 18, 2012> > Source : American Society for Microbiology> > Researchers at Baylor College of Medicine and Texas Children's Hospital> have> identified commensal bacteria in the human intestine that produce a> neurotransmitter> that may play a role in preventing or treating inflammatory bowel> diseases such as> Crohn's disease.> > "We identified, to our knowledge, the first bifidobacterial strain,> Bifidobacterium> dentium, that is capable of secreting large amounts of> gamma-aminobutyric acid> (GABA). This molecule is a major inhibitory neurotransmitter in the> central and> enteric nervous systems," says Karina Pokusaeva, a researcher on the> study and a> member of the laboratory of Versalovic.> > GABA is one of the chief inhibitory neurotransmitters in the human> central nervous> system. It plays a role in regulating pain and some pain relieving drugs> currently> on the market act by targeting GABA receptors on neural cells.> > Pokusaeva and her colleagues were interested in understanding the role> the human> microbiome might play in pain and scanned the genomes of potentially> beneficial> intestinal microorganisms, identified by the Human Microbiome Project,> for evidence> of a gene that would allow them to create GABA.> > "Lab analysis of metagenomic DNA sequencing data allowed us to> demonstrate that> microbial glutamate decarboxylase encoding gene is very abundant in> intestinal> microbiota as compared to other body sites," says Pokusaeva. One of the> most> prolific producers of GABA was B. dentium, which appears to secrete the> compound to> help it survive the acid environment.> > In addition to its pain modulating properties, GABA may also be capable> of> inhibiting inflammation. Recent studies have shown that immune cells> called> macrophages also possess GABA receptors. When these receptors were> activated on the> macrophages there was a decrease in the production of compounds> responsible for> inflammation.> > "Our lab was curious to explore if GABA produced by intestinal human> isolate B.> dentium could have an effect on GABA receptors present in immune cells,"> says> Pokusaeva. Together with their collaborators Dr. Yamada and Dr.> Lacorazza they found> that when the cells were exposed to secretions from the bacteria, they> exhibited> increased expression of the GABAA receptor in the immune cells.> > While the findings are preliminary, they suggest the possibility that B.> dentium and> the compounds it secretes could play a role in reducing inflammation> associated with> inflammatory bowel diseases.> > The next step, says Pokusaeva is to conduct in vitro experiments to> determine if the> increased GABAA expression correlates with a decrease in production of> cytokines> associated with inflammation. GABAA receptor signaling may also> contribute to pain> signaling in the gut and may somehow be involved in abdominal pain> disorders.> > "Our preliminary findings suggest that Bifidobacterium dentium could> potentially> have an inhibitory role in inflammation; however more research has to be> performed> to further prove our hypothesis," says Pokusaeva>