Guest guest Posted March 17, 2006 Report Share Posted March 17, 2006 This is an article I found. I thought it might be of use to those of us in the group. I had never heard of this until I found out this is what is making me so sick and I can not seem to get better from a simple virus! http://www.wisegeek.com/what-is-the-cytokine-storm.htm We think of external microbes as our worst enemy during an outbreak of influenza or bronchitis, but our own immune systems are potentially more lethal. When our body detects foreign microorganisms indicating an infection, it might over-protect our lungs. We race so many antibodies to the site that they collect in a Cytokine storm, potentially blocking airways and causing suffocation. Medical researchers have identified the stages of the Cytokine storm and are working on treatments, other than flu vaccines, to weaken an overactive immune response. At all times, sentries circulate in our bloodstream, called white blood cells, that are the first to sense if a virus or bacteria has infiltrated. Immediately, our body sends defenders from the immune system, T-cells, to the site of the infection. During this stage, our immunity functions properly, and T-cells attack the microbes so they do not get too strong a foothold in our lungs. However, the mere presence of T-cells clustered at one site, especially the lungs, alerts other T-cells that a full-scale war has started. In the second stage, even more T-cells, known as cytokines, flood the lungs. This propagates a Cytokine storm where far too many immune cells are caught in an endless loop of calling even more. The Cytokine storm ends up inflaming the tissue of the lungs and crowding air passages, causing breathing difficulties. Not only can severe inflammation damage your lungs permanently, but a prolonged Cytokine storm will eventually shut down your breathing. Airducts get clogged and cells no longer properly absorb oxygen. This is what makes the Cytokine storm so deadly in certain epidemic strains, such as bird flu. Even bronchitis, other varieties of influenza, pneumonia, and possibly rheumatoid arthritis are susceptible to triggering a Cytokine storm. Of course, flu vaccines are usually effective at preventing the flu during its peak season. But they are no guarantee, especially when flu strains mutate after the vaccine has been manufactured. Therefore, researchers are pursuing other methods of preventing the Cytokine storm by bioengineering a drug that could slow the snowball effect of antibodies. They hope to force the cytokines to recirculate in the bloodstream, rather than pool in the lungs. Experts predict that a major influenza pandemic could kill millions of people worldwide as it has done in centuries past. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 20, 2006 Report Share Posted March 20, 2006 Toni, I'll attempt to answer your question about this soon, but wanted to mention now that this article has many errors - maybe this geek isn't so wise. Not an MD I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] Cytokine Storm > This is an article I found. I thought it might be of use to those of > us in the group. I had never heard of this until I found out this is > what is making me so sick and I can not seem to get better from a > simple virus! > > http://www.wisegeek.com/what-is-the-cytokine-storm.htm > > We think of external microbes as our worst enemy during an outbreak > of influenza or bronchitis, but our own immune systems are > potentially more lethal. When our body detects foreign microorganisms > indicating an infection, it might over-protect our lungs. We race so > many antibodies to the site that they collect in a Cytokine storm, > potentially blocking airways and causing suffocation. Medical > researchers have identified the stages of the Cytokine storm and are > working on treatments, other than flu vaccines, to weaken an > overactive immune response. > > At all times, sentries circulate in our bloodstream, called white > blood cells, that are the first to sense if a virus or bacteria has > infiltrated. Immediately, our body sends defenders from the immune > system, T-cells, to the site of the infection. During this stage, our > immunity functions properly, and T-cells attack the microbes so they > do not get too strong a foothold in our lungs. > > However, the mere presence of T-cells clustered at one site, > especially the lungs, alerts other T-cells that a full-scale war has > started. In the second stage, even more T-cells, known as cytokines, > flood the lungs. This propagates a Cytokine storm where far too many > immune cells are caught in an endless loop of calling even more. The > Cytokine storm ends up inflaming the tissue of the lungs and crowding > air passages, causing breathing difficulties. > > Not only can severe inflammation damage your lungs permanently, but a > prolonged Cytokine storm will eventually shut down your breathing. > Airducts get clogged and cells no longer properly absorb oxygen. This > is what makes the Cytokine storm so deadly in certain epidemic > strains, such as bird flu. Even bronchitis, other varieties of > influenza, pneumonia, and possibly rheumatoid arthritis are > susceptible to triggering a Cytokine storm. > > Of course, flu vaccines are usually effective at preventing the flu > during its peak season. But they are no guarantee, especially when > flu strains mutate after the vaccine has been manufactured. > Therefore, researchers are pursuing other methods of preventing the > Cytokine storm by bioengineering a drug that could slow the snowball > effect of antibodies. They hope to force the cytokines to recirculate > in the bloodstream, rather than pool in the lungs. Experts predict > that a major influenza pandemic could kill millions of people > worldwide as it has done in centuries past. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 20, 2006 Report Share Posted March 20, 2006 Ok, that is good to know...I was searching for more medical abstracts and published journal articles but did not fid much..I know you are the maste and finding correct info. I will be patient and wait for you find some facts. Toni --- In , " " <Matsumura_Clan@...> wrote: > > Toni, I'll attempt to answer your question about this soon, but wanted to > mention now that this article has many errors - maybe this geek isn't so > wise. > > > > Not an MD > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > [ ] Cytokine Storm > > > > This is an article I found. I thought it might be of use to those of > > us in the group. I had never heard of this until I found out this is > > what is making me so sick and I can not seem to get better from a > > simple virus! > > > > http://www.wisegeek.com/what-is-the-cytokine-storm.htm > > > > We think of external microbes as our worst enemy during an outbreak > > of influenza or bronchitis, but our own immune systems are > > potentially more lethal. When our body detects foreign microorganisms > > indicating an infection, it might over-protect our lungs. We race so > > many antibodies to the site that they collect in a Cytokine storm, > > potentially blocking airways and causing suffocation. Medical > > researchers have identified the stages of the Cytokine storm and are > > working on treatments, other than flu vaccines, to weaken an > > overactive immune response. > > > > At all times, sentries circulate in our bloodstream, called white > > blood cells, that are the first to sense if a virus or bacteria has > > infiltrated. Immediately, our body sends defenders from the immune > > system, T-cells, to the site of the infection. During this stage, our > > immunity functions properly, and T-cells attack the microbes so they > > do not get too strong a foothold in our lungs. > > > > However, the mere presence of T-cells clustered at one site, > > especially the lungs, alerts other T-cells that a full-scale war has > > started. In the second stage, even more T-cells, known as cytokines, > > flood the lungs. This propagates a Cytokine storm where far too many > > immune cells are caught in an endless loop of calling even more. The > > Cytokine storm ends up inflaming the tissue of the lungs and crowding > > air passages, causing breathing difficulties. > > > > Not only can severe inflammation damage your lungs permanently, but a > > prolonged Cytokine storm will eventually shut down your breathing. > > Airducts get clogged and cells no longer properly absorb oxygen. This > > is what makes the Cytokine storm so deadly in certain epidemic > > strains, such as bird flu. Even bronchitis, other varieties of > > influenza, pneumonia, and possibly rheumatoid arthritis are > > susceptible to triggering a Cytokine storm. > > > > Of course, flu vaccines are usually effective at preventing the flu > > during its peak season. But they are no guarantee, especially when > > flu strains mutate after the vaccine has been manufactured. > > Therefore, researchers are pursuing other methods of preventing the > > Cytokine storm by bioengineering a drug that could slow the snowball > > effect of antibodies. They hope to force the cytokines to recirculate > > in the bloodstream, rather than pool in the lungs. Experts predict > > that a major influenza pandemic could kill millions of people > > worldwide as it has done in centuries past. > Quote Link to comment Share on other sites More sharing options...
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