Re: Intestinal Bacteria Produce Neurotransmitt...

[Guest guest]

Natasa, are you suggesting probiotic suppositories- i think you have mentioned

this in a previous thread. Would the good bacteria get to the 'right' place?

I'm tempted to try it while my boy is still smallish.

nah

> >> >

> >> >

> >> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In

> >> > Inflammation

> >> >

> >> > Monday, June 18, 2012

> >> >

> >> > Source : American Society for Microbiology

> >> >

> >> > Researchers at Baylor College of Medicine and Texas Children's Hospital

> >> > have

> >> > identified commensal bacteria in the human intestine that produce a

> >> > neurotransmitter

> >> > that may play a role in preventing or treating inflammatory bowel

> >> > diseases such as

> >> > Crohn's disease.

> >> >

> >> > " We identified, to our knowledge, the first bifidobacterial strain,

> >> > Bifidobacterium

> >> > dentium, that is capable of secreting large amounts of

> >> > gamma-aminobutyric acid

> >> > (GABA). This molecule is a major inhibitory neurotransmitter in the

> >> > central and

> >> > enteric nervous systems, " says Karina Pokusaeva, a researcher on the

> >> > study and a

> >> > member of the laboratory of Versalovic.

> >> >

> >> > GABA is one of the chief inhibitory neurotransmitters in the human

> >> > central nervous

> >> > system. It plays a role in regulating pain and some pain relieving drugs

> >> > currently

> >> > on the market act by targeting GABA receptors on neural cells.

> >> >

> >> > Pokusaeva and her colleagues were interested in understanding the role

> >> > the human

> >> > microbiome might play in pain and scanned the genomes of potentially

> >> > beneficial

> >> > intestinal microorganisms, identified by the Human Microbiome Project,

> >> > for evidence

> >> > of a gene that would allow them to create GABA.

> >> >

> >> > " Lab analysis of metagenomic DNA sequencing data allowed us to

> >> > demonstrate that

> >> > microbial glutamate decarboxylase encoding gene is very abundant in

> >> > intestinal

> >> > microbiota as compared to other body sites, " says Pokusaeva. One of the

> >> > most

> >> > prolific producers of GABA was B. dentium, which appears to secrete the

> >> > compound to

> >> > help it survive the acid environment.

> >> >

> >> > In addition to its pain modulating properties, GABA may also be capable

> >> > of

> >> > inhibiting inflammation. Recent studies have shown that immune cells

> >> > called

> >> > macrophages also possess GABA receptors. When these receptors were

> >> > activated on the

> >> > macrophages there was a decrease in the production of compounds

> >> > responsible for

> >> > inflammation.

> >> >

> >> > " Our lab was curious to explore if GABA produced by intestinal human

> >> > isolate B.

> >> > dentium could have an effect on GABA receptors present in immune cells, "

> >> > says

> >> > Pokusaeva. Together with their collaborators Dr. Yamada and Dr.

> >> > Lacorazza they found

> >> > that when the cells were exposed to secretions from the bacteria, they

> >> > exhibited

> >> > increased expression of the GABAA receptor in the immune cells.

> >> >

> >> > While the findings are preliminary, they suggest the possibility that B.

> >> > dentium and

> >> > the compounds it secretes could play a role in reducing inflammation

> >> > associated with

> >> > inflammatory bowel diseases.

> >> >

> >> > The next step, says Pokusaeva is to conduct in vitro experiments to

> >> > determine if the

> >> > increased GABAA expression correlates with a decrease in production of

> >> > cytokines

> >> > associated with inflammation. GABAA receptor signaling may also

> >> > contribute to pain

> >> > signaling in the gut and may somehow be involved in abdominal pain

> >> > disorders.

> >> >

> >> > " Our preliminary findings suggest that Bifidobacterium dentium could

> >> > potentially

> >> > have an inhibitory role in inflammation; however more research has to be

> >> > performed

> >> > to further prove our hypothesis, " says Pokusaeva

> >> >

> >

> >

>

[Guest guest]

I don't know enough about it to suggest it (as in good idea), but worth googling etc?Reply-To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Date: Wed, 27 Jun 2012 12:45:40 -0000To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Subject: Re: Intestinal Bacteria Produce Neurotransmitt...

Natasa, are you suggesting probiotic suppositories- i think you have mentioned this in a previous thread. Would the good bacteria get to the 'right' place?

I'm tempted to try it while my boy is still smallish.

nah

> >> >

> >> >

> >> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In

> >> > Inflammation

> >> >

> >> > Monday, June 18, 2012

> >> >

> >> > Source : American Society for Microbiology

> >> >

> >> > Researchers at Baylor College of Medicine and Texas Children's Hospital

> >> > have

> >> > identified commensal bacteria in the human intestine that produce a

> >> > neurotransmitter

> >> > that may play a role in preventing or treating inflammatory bowel

> >> > diseases such as

> >> > Crohn's disease.

> >> >

> >> > "We identified, to our knowledge, the first bifidobacterial strain,

> >> > Bifidobacterium

> >> > dentium, that is capable of secreting large amounts of

> >> > gamma-aminobutyric acid

> >> > (GABA). This molecule is a major inhibitory neurotransmitter in the

> >> > central and

> >> > enteric nervous systems," says Karina Pokusaeva, a researcher on the

> >> > study and a

> >> > member of the laboratory of Versalovic.

> >> >

> >> > GABA is one of the chief inhibitory neurotransmitters in the human

> >> > central nervous

> >> > system. It plays a role in regulating pain and some pain relieving drugs

> >> > currently

> >> > on the market act by targeting GABA receptors on neural cells.

> >> >

> >> > Pokusaeva and her colleagues were interested in understanding the role

> >> > the human

> >> > microbiome might play in pain and scanned the genomes of potentially

> >> > beneficial

> >> > intestinal microorganisms, identified by the Human Microbiome Project,

> >> > for evidence

> >> > of a gene that would allow them to create GABA.

> >> >

> >> > "Lab analysis of metagenomic DNA sequencing data allowed us to

> >> > demonstrate that

> >> > microbial glutamate decarboxylase encoding gene is very abundant in

> >> > intestinal

> >> > microbiota as compared to other body sites," says Pokusaeva. One of the

> >> > most

> >> > prolific producers of GABA was B. dentium, which appears to secrete the

> >> > compound to

> >> > help it survive the acid environment.

> >> >

> >> > In addition to its pain modulating properties, GABA may also be capable

> >> > of

> >> > inhibiting inflammation. Recent studies have shown that immune cells

> >> > called

> >> > macrophages also possess GABA receptors. When these receptors were

> >> > activated on the

> >> > macrophages there was a decrease in the production of compounds

> >> > responsible for

> >> > inflammation.

> >> >

> >> > "Our lab was curious to explore if GABA produced by intestinal human

> >> > isolate B.

> >> > dentium could have an effect on GABA receptors present in immune cells,"

> >> > says

> >> > Pokusaeva. Together with their collaborators Dr. Yamada and Dr.

> >> > Lacorazza they found

> >> > that when the cells were exposed to secretions from the bacteria, they

> >> > exhibited

> >> > increased expression of the GABAA receptor in the immune cells.

> >> >

> >> > While the findings are preliminary, they suggest the possibility that B.

> >> > dentium and

> >> > the compounds it secretes could play a role in reducing inflammation

> >> > associated with

> >> > inflammatory bowel diseases.

> >> >

> >> > The next step, says Pokusaeva is to conduct in vitro experiments to

> >> > determine if the

> >> > increased GABAA expression correlates with a decrease in production of

> >> > cytokines

> >> > associated with inflammation. GABAA receptor signaling may also

> >> > contribute to pain

> >> > signaling in the gut and may somehow be involved in abdominal pain

> >> > disorders.

> >> >

> >> > "Our preliminary findings suggest that Bifidobacterium dentium could

> >> > potentially

> >> > have an inhibitory role in inflammation; however more research has to be

> >> > performed

> >> > to further prove our hypothesis," says Pokusaeva

> >> >

> >

> >

>

[Guest guest]

Fecal transplantation sounds a bit off the wall but does anyone know someone who

would do it in the UK?

Peta

> >> >

> >> >

> >> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In

> >> > Inflammation

> >> >

> >> > Monday, June 18, 2012

> >> >

> >> > Source : American Society for Microbiology

> >> >

> >> > Researchers at Baylor College of Medicine and Texas Children's Hospital

> >> > have

> >> > identified commensal bacteria in the human intestine that produce a

> >> > neurotransmitter

> >> > that may play a role in preventing or treating inflammatory bowel

> >> > diseases such as

> >> > Crohn's disease.

> >> >

> >> > " We identified, to our knowledge, the first bifidobacterial strain,

> >> > Bifidobacterium

> >> > dentium, that is capable of secreting large amounts of

> >> > gamma-aminobutyric acid

> >> > (GABA). This molecule is a major inhibitory neurotransmitter in the

> >> > central and

> >> > enteric nervous systems, " says Karina Pokusaeva, a researcher on the

> >> > study and a

> >> > member of the laboratory of Versalovic.

> >> >

> >> > GABA is one of the chief inhibitory neurotransmitters in the human

> >> > central nervous

> >> > system. It plays a role in regulating pain and some pain relieving drugs

> >> > currently

> >> > on the market act by targeting GABA receptors on neural cells.

> >> >

> >> > Pokusaeva and her colleagues were interested in understanding the role

> >> > the human

> >> > microbiome might play in pain and scanned the genomes of potentially

> >> > beneficial

> >> > intestinal microorganisms, identified by the Human Microbiome Project,

> >> > for evidence

> >> > of a gene that would allow them to create GABA.

> >> >

> >> > " Lab analysis of metagenomic DNA sequencing data allowed us to

> >> > demonstrate that

> >> > microbial glutamate decarboxylase encoding gene is very abundant in

> >> > intestinal

> >> > microbiota as compared to other body sites, " says Pokusaeva. One of the

> >> > most

> >> > prolific producers of GABA was B. dentium, which appears to secrete the

> >> > compound to

> >> > help it survive the acid environment.

> >> >

> >> > In addition to its pain modulating properties, GABA may also be capable

> >> > of

> >> > inhibiting inflammation. Recent studies have shown that immune cells

> >> > called

> >> > macrophages also possess GABA receptors. When these receptors were

> >> > activated on the

> >> > macrophages there was a decrease in the production of compounds

> >> > responsible for

> >> > inflammation.

> >> >

> >> > " Our lab was curious to explore if GABA produced by intestinal human

> >> > isolate B.

> >> > dentium could have an effect on GABA receptors present in immune cells, "

> >> > says

> >> > Pokusaeva. Together with their collaborators Dr. Yamada and Dr.

> >> > Lacorazza they found

> >> > that when the cells were exposed to secretions from the bacteria, they

> >> > exhibited

> >> > increased expression of the GABAA receptor in the immune cells.

> >> >

> >> > While the findings are preliminary, they suggest the possibility that B.

> >> > dentium and

> >> > the compounds it secretes could play a role in reducing inflammation

> >> > associated with

> >> > inflammatory bowel diseases.

> >> >

> >> > The next step, says Pokusaeva is to conduct in vitro experiments to

> >> > determine if the

> >> > increased GABAA expression correlates with a decrease in production of

> >> > cytokines

> >> > associated with inflammation. GABAA receptor signaling may also

> >> > contribute to pain

> >> > signaling in the gut and may somehow be involved in abdominal pain

> >> > disorders.

> >> >

> >> > " Our preliminary findings suggest that Bifidobacterium dentium could

> >> > potentially

> >> > have an inhibitory role in inflammation; however more research has to be

> >> > performed

> >> > to further prove our hypothesis, " says Pokusaeva

> >> >

> >

> >

>

[Guest guest]

Dr Alisdair MacConnachie at Gartnaval Hospital, Glasgow.

Kasia

>

> Fecal transplantation sounds a bit off the wall but does anyone know someone

who would do it in the UK?

> Peta

>

[Guest guest]

Thanks for that. Do you see him for treating your child either privately or on

the NHS? Are you considering having it done?

Peta

> >

> > Fecal transplantation sounds a bit off the wall but does anyone know someone

who would do it in the UK?

> > Peta

> >

>

[Guest guest]

I googled Dr Macconnachie re the transplants and it sounds interesting, 11 out

of 15 patients were cured of CDAD ( clostridia difficile associated diahorrea).

It's sounds a disgusting thing to do but if it's harmless and relatively simple

then I think it's worth a go. Is anyone else considering having it done? Now to

try to get a referral. I wonder if he will do it for autistic children

> >

> > Fecal transplantation sounds a bit off the wall but does anyone know someone

who would do it in the UK?

> > Peta

> >

>

[Guest guest]

Hi,

It's been discussed here in Norfolk with adult gastro and psychiatrist but their current thinking is the results aren't yet sufficient - results for C diff for example, do not directly relate to IBS/D or SIBO, whichis what we were talking about.

Patience

[Guest guest]

I think, with my son, it would be externally difficult to do it on the NS or

privately in the UK. His symptoms are not severe and the pead isn't doing

anything about them (mostly sore tummy and diarrhea if he doesn't take LOTS of

probiotics), she refused to prescribe VSL3 and I do not want to do NHS

investigation of his digestive issues as I see that more often than not they do

not bring proper treatment anyway. I will wait for seeing Dr G and the results

of the new tests. What I noticed is that for some reason my son does not keep

the friendly bacteria for long. I have a file how to do the transplant yourself

if you are interested- it's from Crohn's group by some dr who does it in the

States, can dig it out (hopefully), but the donor have to be tasted for all

kinds of stuff and it's best if the donor is a family member.

Kasia

> > >

> > > Fecal transplantation sounds a bit off the wall but does anyone know

someone who would do it in the UK?

> > > Peta

> > >

> >

>

[Guest guest]

Thanks Kaisa,

I don't have a paed anymore but my doctor is ok and will refer me to places,

usually. I don't think I'd like to do it myself. I think I'll phone Dr

MacConnachie and ask him or his secretary - shy bairns get nowt!

Peta

> > > >

> > > > Fecal transplantation sounds a bit off the wall but does anyone know

someone who would do it in the UK?

> > > > Peta

> > > >

> > >

> >

>

[Guest guest]

BioCare sells probiotic for colonic therapy:

http://www.nutritioncentre.co.uk/p/1808/Biocare-Implant.html

Kasia

> > >> >

> > >> >

> > >> > Intestinal Bacteria Produce Neurotransmitter, Could Play Role In

> > >> > Inflammation

> > >> >

> > >> > Monday, June 18, 2012

> > >> >

> > >> > Source : American Society for Microbiology

> > >> >

> > >> > Researchers at Baylor College of Medicine and Texas Children's

Hospital

> > >> > have

> > >> > identified commensal bacteria in the human intestine that produce a

> > >> > neurotransmitter

> > >> > that may play a role in preventing or treating inflammatory bowel

> > >> > diseases such as

> > >> > Crohn's disease.

> > >> >

> > >> > " We identified, to our knowledge, the first bifidobacterial strain,

> > >> > Bifidobacterium

> > >> > dentium, that is capable of secreting large amounts of

> > >> > gamma-aminobutyric acid

> > >> > (GABA). This molecule is a major inhibitory neurotransmitter in the

> > >> > central and

> > >> > enteric nervous systems, " says Karina Pokusaeva, a researcher on the

> > >> > study and a

> > >> > member of the laboratory of Versalovic.

> > >> >

> > >> > GABA is one of the chief inhibitory neurotransmitters in the human

> > >> > central nervous

> > >> > system. It plays a role in regulating pain and some pain relieving

drugs

> > >> > currently

> > >> > on the market act by targeting GABA receptors on neural cells.

> > >> >

> > >> > Pokusaeva and her colleagues were interested in understanding the role

> > >> > the human

> > >> > microbiome might play in pain and scanned the genomes of potentially

> > >> > beneficial

> > >> > intestinal microorganisms, identified by the Human Microbiome Project,

> > >> > for evidence

> > >> > of a gene that would allow them to create GABA.

> > >> >

> > >> > " Lab analysis of metagenomic DNA sequencing data allowed us to

> > >> > demonstrate that

> > >> > microbial glutamate decarboxylase encoding gene is very abundant in

> > >> > intestinal

> > >> > microbiota as compared to other body sites, " says Pokusaeva. One of

the

> > >> > most

> > >> > prolific producers of GABA was B. dentium, which appears to secrete

the

> > >> > compound to

> > >> > help it survive the acid environment.

> > >> >

> > >> > In addition to its pain modulating properties, GABA may also be

capable

> > >> > of

> > >> > inhibiting inflammation. Recent studies have shown that immune cells

> > >> > called

> > >> > macrophages also possess GABA receptors. When these receptors were

> > >> > activated on the

> > >> > macrophages there was a decrease in the production of compounds

> > >> > responsible for

> > >> > inflammation.

> > >> >

> > >> > " Our lab was curious to explore if GABA produced by intestinal human

> > >> > isolate B.

> > >> > dentium could have an effect on GABA receptors present in immune

cells, "

> > >> > says

> > >> > Pokusaeva. Together with their collaborators Dr. Yamada and Dr.

> > >> > Lacorazza they found

> > >> > that when the cells were exposed to secretions from the bacteria, they

> > >> > exhibited

> > >> > increased expression of the GABAA receptor in the immune cells.

> > >> >

> > >> > While the findings are preliminary, they suggest the possibility that

B.

> > >> > dentium and

> > >> > the compounds it secretes could play a role in reducing inflammation

> > >> > associated with

> > >> > inflammatory bowel diseases.

> > >> >

> > >> > The next step, says Pokusaeva is to conduct in vitro experiments to

> > >> > determine if the

> > >> > increased GABAA expression correlates with a decrease in production of

> > >> > cytokines

> > >> > associated with inflammation. GABAA receptor signaling may also

> > >> > contribute to pain

> > >> > signaling in the gut and may somehow be involved in abdominal pain

> > >> > disorders.

> > >> >

> > >> > " Our preliminary findings suggest that Bifidobacterium dentium could

> > >> > potentially

> > >> > have an inhibitory role in inflammation; however more research has to

be

> > >> > performed

> > >> > to further prove our hypothesis, " says Pokusaeva

> > >> >

> > >

> > >

> >

>

[Guest guest]

Hi,

http://drbradstreet.org/2012/06/26/whats-wrong-with-the-gut-of-children-with-aut\

ism/

I came across this via a link from Whiteley's Questioning Answers blog

It answers a lot of practical questions - hope it's helpful.

Patience

> > > > >

> > > > > Fecal transplantation sounds a bit off the wall but does anyone know

someone who would do it in the UK?

> > > > > Peta

> > > > >

> > > >

> > >

> >

>