RESEARCH - Synovial fluid levels of anti-CCP and RF in RA, PsA, and OA

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Arthritis Rheum. 2006 Feb;55(1):53-6.

Synovial fluid levels of anti-cyclic citrullinated peptide antibodies and

IgA rheumatoid factor in rheumatoid arthritis, psoriatic arthritis, and

osteoarthritis.

Caspi D, Anouk M, Golan I, Paran D, Kaufman I, Wigler I, Levartovsky D,

Litinsky I, Elkayam O.

Tel Aviv " Sourasky " Medical Center and the " Sackler " Faculty of Medicine,

University of Tel Aviv, Tel Aviv, Israel.

OBJECTIVE: To assess the levels of anti-cyclic citrullinated peptide

(anti-CCP) and IgA rheumatoid factor (IgA-RF) in synovial fluids of patients

with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and

osteoarthritis (OA). METHODS: Knee effusions of 29 patients with RA (23

women, 6 men; mean +/- SD age 60 +/- 15 years), 20 with PsA (6 women, 14

men; mean age 51 +/- 12 years), and 19 with OA (9 women, 10 men; mean age 73

+/- 11.8 years) were aspirated, tested for white blood cell (WBC) counts,

centrifuged, and stored at -20 degrees . Sera of 22, 11, and 12 of these

patients with RA, PsA, and OA, respectively, were similarly stored. IgG

anti-CCP and IgA-RF were detected by enzyme-linked immunosorbent assay.

Erythrocyte sedimentation rate and C-reactive protein levels were used as

measures of disease activity. RESULTS: Mean levels of synovial fluid

anti-CCP and IgA-RF were significantly increased in RA joint effusions

compared with PsA and OA (anti-CCP: 150 +/- 134, 34 +/- 29, and 24 +/- 26

units, respectively [P < 0.003]; IgA-RF: 76 +/- 77, 15.7 +/- 10, and 18 +/-

20 units, respectively). No significant difference was noted between OA and

PsA. A significant correlation was found between synovial fluid anti-CCP and

serum anti-CCP and IgA-RF. In patients with RA, a significant correlation

was found between synovial fluid WBC counts and IgA-RF (P = 0.03) and serum

IgA-RF (P = 0.008), but not between synovial fluid and serum anti-CCP

levels. In RA patients, C-reactive protein correlated with serum IgA-RF.

CONCLUSION: Anti-CCP and IgA-RF were significantly increased in synovial

fluid of RA in comparison with PsA and OA patients.

PMID: 16463412

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6463412 & dopt=Abstract

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