Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 , Sorry that I'll be giving you an unsatisfying answer: I don't know. I'm not sure if anyone does. Humira was developed as the first " fully human " monoclonal antibody to treat RA with the hopes that immunogenicity would not be a problem; however, immunogenicity seems to be an issue for all three anti-TNF agents, including Humira. The extent of the problem is still being investigated. There also seems to be a synergistic effect when MTX is added. That is still being pondered and studied. So many mysteries. In any case, I'll post some of the relevant articles, so you can have a better sense of what is known. Good luck! I hope Humira works very well for you. Not an MD I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] MTX & Humira - to > Hi , > > I will be starting on Humira tomorrow after a 4 month trial on > Enbrel that was not that successful. (it helped some, but not nearly > enough) I have been on 20 mg(.8 ml)MTX for quite a while now, but my > liver values are heading up again. My doc told me to cut the MTX > back down to 15 mg per week. Is there some magic number in terms of > how much MTX seems to make the Humira work better? Or is that a > matter of trial and error too? > > My liver values went WAY out of whack on Arava, but seemed to settle > back down once I had been off the Arava for a while, even though I > remained on the MTX. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 Thanks as always, ! > > , > > Sorry that I'll be giving you an unsatisfying answer: I don't know. I'm not > sure if anyone does. > > Humira was developed as the first " fully human " monoclonal antibody to treat > RA with the hopes that immunogenicity would not be a problem; however, > immunogenicity seems to be an issue for all three anti-TNF agents, including > Humira. The extent of the problem is still being investigated. > > There also seems to be a synergistic effect when MTX is added. That is still > being pondered and studied. > > So many mysteries. > > In any case, I'll post some of the relevant articles, so you can have a > better sense of what is known. > > Good luck! I hope Humira works very well for you. > > > > Not an MD > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > [ ] MTX & Humira - to > > > > Hi , > > > > I will be starting on Humira tomorrow after a 4 month trial on > > Enbrel that was not that successful. (it helped some, but not nearly > > enough) I have been on 20 mg(.8 ml)MTX for quite a while now, but my > > liver values are heading up again. My doc told me to cut the MTX > > back down to 15 mg per week. Is there some magic number in terms of > > how much MTX seems to make the Humira work better? Or is that a > > matter of trial and error too? > > > > My liver values went WAY out of whack on Arava, but seemed to settle > > back down once I had been off the Arava for a while, even though I > > remained on the MTX. > > > > > Quote Link to comment Share on other sites More sharing options...
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