Ginkgo-like DRUG trial for boosting DS cognition: in UK, US

[Guest guest]

reposting this clinical trial by Roche with some comments. The trial is for boosting of cognitive performance of persons with DS by administering a GABA antagonist (turns down GABA). Gee, some of us

have already been doing this a long time. Ginkgo Biloba is a natural GABA antagonist, BUT here's how I understand it. Unlike a drug (which has to be dosed carefully and monitored) Ginkgo does not totally block GABA just some of it. GABA is overexpressed in our kids, and needs to be turned down. But GABA is

totally necessary in the synapses as you know, or else the neuron is left defenseless against overexcitability (which damages or kills the neuron). According to Cody's presentation, GABA receptors are everywhere! Central Nervous System (brain)

Airway Epithelium

Stomach

Small Intestine

Large Intestine

Bladder

Pancreas

Type II Alveolar Epithelium (lung)

Liver

Lungs

Skin

Eyes

Retina

Esophagus

Vagal Pathways

Laryngeal motorneurons

muscleand here is what she writes about what GABA's role in various systems

Organ or physical area

GABA A & B Receptor

Symptoms

Central Nervous System (brain)

Inhibitor

Sleepiness, drowsiness, sedative

Airway Epithelium

Excitatory

Produces mucous

Decreases tone of smooth muscle

Stomach

GABA A -relaxation

GABA B - ↑muscle tone

GABA can cause stomach upset

muscle

↑GABA

↓ muscle tone

Lungs

↓GABA bronchial smooth muscle

Shortness of breath

Bladder

inhibitions of urination with increases in bladder capacity

Esophagus

Reflux

Anyway, here is the GABA inhibition drug trial in UK and US. Thanks from the DSTNI list for this. <http://www.roche-trials.com/trialDetailsGet.action?studyNumber=BP25543 & diseaseCategoryId=266>I put this out there for informational purposes only. Personally, I'm not a big fan of pharmaceutical companies or their drugs, so I'll stick with Ginkgo Biloba (standardized extract, Honeycombs liquid brand) for our kiddo. Yet, this trial does give huge credence to those of us supplementing with Ginkgo B already. Take notice, the Buckleys of the

world (I don't mean to attack....he and DSEI I must believe are good people in their own way, yet have vigorously taking every opportunity to discourage parents from any sort of Nutritional or herbal therapy, TNI, CMP, anything "unproven" - even harsh words for Neurodevelopmental therapy, etc. I wonder if they'll change their tune when the drug becomes an "approved therapy" meaning it is controlled by doctors, and makes yet another corporation, this time Roche, a bunch of money). GB Doesn't make the drug companies rich. Works great. I can control exact dosage with the dropper (there are 3.3 mg active GB per drop. Dosage is 5.5 mg per kg body weight, one, two or three times a day). And, GB has

like a 5,000 year safety and efficacy record of usage here in China with Traditional Chinese Medicine. best,Liora PearlmanMom to

Etel age 3y3m (on GB since 13 months)