After vaccination, pigs experience MORE severe disease

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<http://www.ncbi.nlm.nih.gov/pubmed/22461226>Vet Pathol. 2012 Mar 28. [Epub ahead of print]Kinetics of Lung Lesion Development and Pro-Inflammatory Cytokine Response in Pigs With Vaccine-Associated Enhanced Respiratory Disease Induced by Challenge With Pandemic (2009) A/H1N1 Influenza Virus.The objective of this report was to characterize the enhanced clinical disease and lung lesions observed in pigs vaccinated with inactivated H1N2 swine δ-cluster influenza A virus and challenged with pandemic 2009 A/H1N1 human influenza virus......These data suggest H1 inactivated vaccines followed by heterologous challenge resulted in potentiated clinical signs and enhanced pulmonary lesions and correlated with an elevated proinflammatory cytokine response in the lung. The lung pathology and host immune response is consistent with the vaccine-associated enhanced respiratory disease (VAERD) clinical outcome observed reproducibly in our swine model. Liora Pearlman , ModeratorMom Please consider calling me at 5130 3931 or texting 139 1030 6022 if it is time sensitive. Facebook: https://www.facebook.com/liorap2