RESEARCH - Clinical and genetic risk factors of shingles in patients with SLE

April 2, 2006

Rheumatol Int. 2005 Mar;25(2):97-102. Epub 2003 Oct 31.

Clinical and genetic risk factors of herpes zoster in patients with systemic

lupus erythematosus.

Kang TY, Lee HS, Kim TH, Jun JB, Yoo DH.

Hospital for Rheumatic Diseases, Hanyang University Hospital, 17

Haengdang-dong, Seong Dong-ku, Seoul 133-792, Republic of Korea.

OBJECTIVE: The aim of this study was to determine the clinical and genetic

risk factors that influence herpes zoster occurrence in patients with

systemic lupus erythematosus (SLE). METHODS: Three hundred three SLE

patients meeting the American College of Rheumatology criteria were enrolled

in this study. Herpes zoster was diagnosed when classic grouped vesicles

were noted. Medical records were reviewed retrospectively to collect

clinical information. For Fc gamma receptor IIa (Fc gamma RIIa) and Fc gamma

RIIIa genotyping, polymerase chain reaction (PCR) using allele-specific

primers was performed. The PCR sequence-specific oligonucleotide probe

method was utilized in human HLA-DRB1 genotyping. RESULTS: Forty-two cases

(13.9%) of zoster occurred among 303 SLE patients. The incidence of zoster

in patients with SLE was 32.5/1,000 patients per year. Patients who

developed zoster had higher rates of lupus nephritis (P = 0.018) and

positive anti-Sm antibody (P = 0.019). However, Fc gamma RIIa and Fc gamma

RIIIa polymorphism and the HLA-DRB1 genotype did not influence herpes zoster

occurrence. CONCLUSION: Systemic lupus erythematosus patients with lupus

nephritis or anti-Sm antibody are at higher risk of herpes zoster. Fc gamma

RIIa (H/R131), Fc gamma RIIIa (F/V176), and HLA-DRB1 genetic polymorphisms

did not influence the occurrence of herpes zoster in these patients.

PMID: 14593495

4593495 & dopt=Abstract

Not an MD

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Mayo Clinic in Rochester

s Hopkins Medicine

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