INFO - Ultram (tramadol hydrochloride)

[Guest guest]

ULTRAM® is a centrally acting synthetic opioid analgesic. Although its mode

of action is not completely understood, from animal tests,

at least two complementary mechanisms appear applicable: binding of parent

and M1 metabolite to µ-opioid receptors and weak

inhibition of re-uptake of norepinephrine and serotonin.

Opioid activity is due to both low affinity binding of the parent compound

and higher affinity binding of the O-demethylated metabolite

M1 to µ-opioid receptors. In animal models, M1 is up to 6 times more potent

than tramadol in producing analgesia and 200 times

more potent in µ-opioid binding. Tramadol-induced analgesia is only

partially antagonized by the opiate antagonist naloxone in

several animal tests. The relative contribution of both tramadol and M1 to

human analgesia is dependent upon the plasma concentrations

of each compound (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

Tramadol has been shown to inhibit reuptake of norepinephrine and serotonin

in vitro, as have some other opioid analgesics. These

mechanisms may contribute independently to the overall analgesic profile of

ULTRAM. Analgesia in humans begins approximately

within one hour after administration and reaches a peak in approximately two

to three hours.

Apart from analgesia, ULTRAM administration may produce a constellation of

symptoms (including dizziness, somnolence, nausea,

constipation, sweating and pruritus) similar to that of other opioids. In

contrast to morphine, tramadol has not been shown to cause

histamine release. At therapeutic doses, ULTRAM has no effect on heart rate,

left-ventricular function or cardiac index. Orthostatic

hypotension has been observed.

http://www.ortho-mcneil.com/html/comi/products.jsp

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[Guest guest]

Thanks, .

Ultram and Tramodol are the same thing, right?

Maybe the fact that Tramodol doesn't cause histimine release is the

reason it doesn't give me headaches, while percocet does.

>

> ULTRAM® is a centrally acting synthetic opioid analgesic. Although

its mode

> of action is not completely understood, from animal tests,

> at least two complementary mechanisms appear applicable: binding

of parent

> and M1 metabolite to µ-opioid receptors and weak

> inhibition of re-uptake of norepinephrine and serotonin.

>

> Opioid activity is due to both low affinity binding of the parent

compound

> and higher affinity binding of the O-demethylated metabolite

> M1 to µ-opioid receptors. In animal models, M1 is up to 6 times

more potent

> than tramadol in producing analgesia and 200 times

> more potent in µ-opioid binding. Tramadol-induced analgesia is only

> partially antagonized by the opiate antagonist naloxone in

> several animal tests. The relative contribution of both tramadol

and M1 to

> human analgesia is dependent upon the plasma concentrations

> of each compound (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

>

> Tramadol has been shown to inhibit reuptake of norepinephrine and

serotonin

> in vitro, as have some other opioid analgesics. These

> mechanisms may contribute independently to the overall analgesic

profile of

> ULTRAM. Analgesia in humans begins approximately

> within one hour after administration and reaches a peak in

approximately two

> to three hours.

>

> Apart from analgesia, ULTRAM administration may produce a

constellation of

> symptoms (including dizziness, somnolence, nausea,

> constipation, sweating and pruritus) similar to that of other

opioids. In

> contrast to morphine, tramadol has not been shown to cause

> histamine release. At therapeutic doses, ULTRAM has no effect on

heart rate,

> left-ventricular function or cardiac index. Orthostatic

> hypotension has been observed.

>

>

> http://www.ortho-mcneil.com/html/comi/products.jsp

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

[Guest guest]

Yes, Ultram is a brand name. There are others and different formulations.

Ultram = tramadol hydrochloride

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: INFO - Ultram (tramadol hydrochloride)

Thanks, .

Ultram and Tramodol are the same thing, right?

Maybe the fact that Tramodol doesn't cause histimine release is the

reason it doesn't give me headaches, while percocet does.

>

> ULTRAM® is a centrally acting synthetic opioid analgesic. Although

its mode

> of action is not completely understood, from animal tests,

> at least two complementary mechanisms appear applicable: binding

of parent

> and M1 metabolite to µ-opioid receptors and weak

> inhibition of re-uptake of norepinephrine and serotonin.

>

> Opioid activity is due to both low affinity binding of the parent

compound

> and higher affinity binding of the O-demethylated metabolite

> M1 to µ-opioid receptors. In animal models, M1 is up to 6 times

more potent

> than tramadol in producing analgesia and 200 times

> more potent in µ-opioid binding. Tramadol-induced analgesia is only

> partially antagonized by the opiate antagonist naloxone in

> several animal tests. The relative contribution of both tramadol

and M1 to

> human analgesia is dependent upon the plasma concentrations

> of each compound (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

>

> Tramadol has been shown to inhibit reuptake of norepinephrine and

serotonin

> in vitro, as have some other opioid analgesics. These

> mechanisms may contribute independently to the overall analgesic

profile of

> ULTRAM. Analgesia in humans begins approximately

> within one hour after administration and reaches a peak in

approximately two

> to three hours.

>

> Apart from analgesia, ULTRAM administration may produce a

constellation of

> symptoms (including dizziness, somnolence, nausea,

> constipation, sweating and pruritus) similar to that of other

opioids. In

> contrast to morphine, tramadol has not been shown to cause

> histamine release. At therapeutic doses, ULTRAM has no effect on

heart rate,

> left-ventricular function or cardiac index. Orthostatic

> hypotension has been observed.

>

>

> http://www.ortho-mcneil.com/html/comi/products.jsp

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>