INFO - ANA-negative lupus as a distinct diagnostic entity - does it no longer exist?

[Guest guest]

Oxford Journals

QJM

Commentary

2004; 97: 303-308

" Antinuclear antibody-negative lupus as a distinct diagnostic entity - does

it no longer exist? "

Excerpt:

" While the concept of ANA-negative lupus appeared to be a genuine phenomenon

a few decades ago, current evidence from the literature and experience in

large centres29 suggests that true ANA-negative lupus is an extremely rare

event. Indeed, Wallace was recently moved to comment that 'the 1990's saw

the near demise of ANA-negative lupus as human substrates (Hep-2) replaced

animal tissues for detecting ANA'.11 We suspect that Wallace's prophecy will

be fulfilled following the long overdue acceptance by immunology

laboratories that Hep-2 cells are the best substrate for ANA testing. We

have written this commentary in the hope of stimulating discussion on

ANA-negative lupus, and challenging conventional dogma on its prevalence.

If, in the era of Hep-2 cells, it does exist as a distinct entity, it is

time to consider the establishment of a registry of such cases. "

http://qjmed.oxfordjournals.org/cgi/content/full/97/5/303

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[Guest guest]

It does exist the ANA but Lupus hides...it doesnt always show in your relative

new blood tests...as my R/A didnt.

it is through other means like the sed/rate sedimentation rate that this

happens

It took many a while and watching carefully to see my sed rate go from the 40s

to the 20s to the 60s to the 90s and the 20s and the 80s and this happens all

the time

ask your rhuemy about these things.

He/she knows the way your tests are going

Bonnie Sue

---------------------------------

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[Guest guest]

can anyone send me the url to the home page please

Bonnie Sue

---------------------------------

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[Guest guest]

Bonnie Sue,

The group site is here:

That URL appears at the bottom of every E-mail.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] INFO - ANA-negative lupus as a distinct diagnostic

entity - does it no longer exist?

can anyone send me the url to the home page please

Bonnie Sue

[Guest guest]

Seronegative lupus is rare, but seronegative RA is not rare.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] INFO - ANA-negative lupus as a distinct diagnostic

entity - does it no longer exist?

It does exist the ANA but Lupus hides...it doesnt always show in your

relative new blood tests...as my R/A didnt.

it is through other means like the sed/rate sedimentation rate that this

happens

It took many a while and watching carefully to see my sed rate go from the

40s to the 20s to the 60s to the 90s and the 20s and the 80s and this

happens all the time

ask your rhuemy about these things.

He/she knows the way your tests are going

Bonnie Sue