RESEARCH - Influence of HLA-DRB1 on the susceptibility to RA and on the production of anti-CCP antibodies

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Ann Rheum Dis. 2006 Jun 22; [Epub ahead of print]

Influence of Human Leukocyte Antigen-DRB1 on the susceptibility to

rheumatoid arthritis and on the production of anti-cyclic citrullinated

peptide antibodies in a Portuguese population.

Ligeiro DA, Fonseca JE, Abade O, Abreu I, Cruz M, Nero P, Cavaleiro J, Teles

J, Trindade H, Caetano M, Branco J.

Centro de Histocompatibilidade do Sul, Portugal.

OBJECTIVE: To clarify the influence of the HLA- DRB1 locus on the

susceptibility to rheumatoid arthritis (RA) and the production of

anti-cyclic citrullinated peptide antibodies (anti-CCP) in a Portuguese

population. METHODS: 141 RA patients fulfilling the American College of

Rheumatology 1987 revised criteria for RA were compared with 150 healthy

controls. HLA-DRB1 locus genotyping was assessed by PCR reverse probing

assays and sequence specific primers. Anti-CCP antibodies were quantified by

ELISA in RA patients. Comparisons of the frequencies between groups were

evaluated by the two-sided Fisher's exact test and considered significant if

p<0.05. RESULTS: The HLA-DRB1*04 group and HLA-DRB1*10 were highly

associated with RA (respectively p<0.0001 and p=0.031). High titres of

anti-CCP antibodies, were significantly associated with the presence of HLA-

DRB1*04/10.

CONCLUSION: The well recognized susceptibility alleles to RA, HLA-DRB1*04,

were associated to RA in Portuguese patients. The relatively rare DRB1*10

was also associated with RA, as it was previously described in other

Southern European countries. Both groups were associated with high anti-CCP

titres, reinforcing its relevance to disease onset.

PMID: 16793843

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6793843

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