sulfasalazine

[Guest guest]

I dont post very often but 3 weeks ago I was given

sulfazalazine as well as the methotrexate I am already

on. I have been building it up to 3 per day. However

today I feel ill and very nauseous. Has anyone any

knowledge of this drug. I was given a leaflet with

the meds but it doesnt say very much. Would

appreciate any advice

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[Guest guest]

I take sulfasalazine twice a day along with other meds.

I am supposed to take it four times a day.

If I take more than two a day, one in the a.m. and one in the p.m.

I get very nauseous. Also, I have to take folic acid once a day

while taking

the sulfasalazine

Khaki

---------------------------------

Stay in the know. Pulse on the new .com. Check it out.

[Guest guest]

Hi,

I was on it, for one gave me heart burn had to take privosac (not sure of

spelling) everyday or I was in alot of discomfort. Since he changed me to

Methotrexate (which is working much better) I have had any heartburn. Heartburn

was something I did not have before if I did it was a small case and alittle bit

of water would take care of it (that is how mild it was before the

Sulfasalazine.

Hope this helps.

Marsha

[ ] sulfasalazine

Does anyone have any experiences they can share about it?

Thanks.

[Guest guest]

I am much happier on sulfasalazine than I was on plaquenal.

Marsha Hostetler <marshahostetler@...> wrote: Hi,

I was on it, for one gave me heart burn had to take privosac (not sure of

spelling) everyday or I was in alot of discomfort. Since he changed me to

Methotrexate (which is working much better) I have had any heartburn. Heartburn

was something I did not have before if I did it was a small case and alittle bit

of water would take care of it (that is how mild it was before the

Sulfasalazine.

Hope this helps.

Marsha

[ ] sulfasalazine

Does anyone have any experiences they can share about it?

Thanks.

[Guest guest]

>

> Does anyone have any experiences they can share about it?

>

> Thanks.

>

Hi I Have been recently diagnosed with RA and im taking

sulfasalazine/salazopyrin and all i can tell you is that you have to

gradually increase the dose over a month untill you reach the max dose

of four tablets a day, i found that the first three weeks of taking it

i felt quite sick. But it soon subsides, it also changes the colour of

your urine to a very dark orange which i found quite alarming at

first , but is common. As you probably know it takes three/four months

to work and i think its too early too tell with me. Ive only been

taking them for 3 months. Does it work for you?

[Guest guest]

I haven't gotten on it. My rheumy is considering it for my next visit

in a couple of months so I am trying to get as much info as I can. I

have MCTD with my primary problem being RA.

Thanks for all those who responded. Anyone else?

> >

> > Does anyone have any experiences they can share about it?

> >

> > Thanks.

> >

> Hi I Have been recently diagnosed with RA and im taking

> sulfasalazine/salazopyrin and all i can tell you is that you have

to

> gradually increase the dose over a month untill you reach the max

dose

> of four tablets a day, i found that the first three weeks of taking

it

> i felt quite sick. But it soon subsides, it also changes the colour

of

> your urine to a very dark orange which i found quite alarming at

> first , but is common. As you probably know it takes three/four

months

> to work and i think its too early too tell with me. Ive only been

> taking them for 3 months. Does it work for you?

>

[Guest guest]

I got a bad rash that started on my feet and spread all the way up. I

believe it was from the sulfasalazine, but I get all sorts of rashes easily.

[ ] Re: sulfasalazine

>I haven't gotten on it. My rheumy is considering it for my next visit

> in a couple of months so I am trying to get as much info as I can. I

> have MCTD with my primary problem being RA.

>

> Thanks for all those who responded. Anyone else?

[Guest guest]

I do think it was the sulfasalazine. Now when asked if I'm allergic, I

always put " sulfa drugs " on the list. Yes, it was very bad and very itchy.

> Maybe you are allergic to sulfa drugs if sulfasalazine gave you a bad

> rash. Seprta and Bectrim are sulfa drugs which gave me a bad, very

> itchy rash.

>

> Debbie L

[Guest guest]

I don't remember what it did to me, but I only took it for about a week

about 4 years ago. I couldn't take it any more, and gave the bottle to the

Rummy to give another patient. I know it wasn't a rash, though, I would have

remembered that.

Dennis in Eastexas

" It's not Rocket Surgery "

[ ] Re: sulfasalazine

> Maybe you are allergic to sulfa drugs if sulfasalazine gave you a bad

> rash. Seprta and Bectrim are sulfa drugs which gave me a bad, very

> itchy rash.

>

> Debbie L

>

>

>

>>

>> I got a bad rash that started on my feet and spread all the way up.

> I

>> believe it was from the sulfasalazine, but I get all sorts of rashes

> easily.

[Guest guest]

I've been on Sulfasalazine for a coule of years and it hasn't

disrupted my sleep like that. But drugs can affect people

differently. I get horrible methotrexate side effects and had to stop

taking it (headache, nauscious) while a friend takes methotrexate and

has no side effects.

I wasn't sure the Sulfasalize was working and stopped taking it (with

my doctor's permission) but soon felt much more pain and joint

swelling so I started taking it again.

Sorry about your daughter!

On Thu, Feb 28, 2008 at 1:53 PM, <jennyherd@...> wrote:

>

>

>

>

> Hi All

>

> Am wondering about other member's experience with Sulfasalazine

> (Salazopyrin).

>

> My daughter was put on this drug in an attempt to control a mystery

> condition (aka the doctors have NO idea what on earth is going on).

> She was on a half dose for the first week and started having trouble

> getting to sleep. It slowly got worse during that week. When the dose

> doubled in the second week all hell broke loose. By the end of the

> third week she hadn't slept for 4 days/nights AT ALL. I got no

> response from the doctor when I called (took him a week to ph me back)

> so I decided to take her off it. It took 4 weeks until she returned to

> normal. It was a terrifying experience. The doctor's comment was " Well

> it's not a KNOWN side effect " Guess what? I fired him.

>

> I look forward to hearing if anyone else has had an experience similar

> to this.

>

> Melbourne, Australia

>

>

[Guest guest]

I'm sorry she had such an awful experience! I began

plaquenil for over a year and when that didn't work my

doctor added Sulfasalazine. I started on 2000mgs

right away. It took 6 months to work at all in my

system as it needed to build up. Right before I got

to the six month mark, my doctor increased the

medication to 3000mgs because 2000 was not enough. I

ahd to stop taking it for three months due to

bronchitis. I had so much pain when not being able to

take it. Once I restarted it, it took about a week

and it was back to working. I have to have a CBC

blood test done every two weeks to monitor any

sideeffects the medication may be causing though. I'm

not sure it would have affected my sleep since I have

been taking Lunesta for a couple of years now. I hope

they find something to help her soon:)

--- <jennyherd@...> wrote:

> Hi All

>

> Am wondering about other member's experience with

> Sulfasalazine

> (Salazopyrin).

>

> My daughter was put on this drug in an attempt to

> control a mystery

> condition (aka the doctors have NO idea what on

> earth is going on).

> She was on a half dose for the first week and

> started having trouble

> getting to sleep. It slowly got worse during that

> week. When the dose

> doubled in the second week all hell broke loose. By

> the end of the

> third week she hadn't slept for 4 days/nights AT

> ALL. I got no

> response from the doctor when I called (took him a

> week to ph me back)

> so I decided to take her off it. It took 4 weeks

> until she returned to

> normal. It was a terrifying experience. The doctor's

> comment was " Well

> it's not a KNOWN side effect " Guess what? I fired

> him.

>

> I look forward to hearing if anyone else has had an

> experience similar

> to this.

>

> Melbourne, Australia

>

>

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[Guest guest]

Hello and sorry to hear about your daughter and her experience. I take

Sulfasalazine 500mg four pills a day and I haven't noticed any huge changes in

my sleep. to be honest sometimes I wonder if I have any changes with this

medication--I also take Humira and predisone.

Well good for you for sticking up for your child, hopefully you will find a

doctor who does care and is willing to go that extra mile for your daughter.

<jennyherd@...> wrote: Hi

All

Am wondering about other member's experience with Sulfasalazine

(Salazopyrin).

My daughter was put on this drug in an attempt to control a mystery

condition (aka the doctors have NO idea what on earth is going on).

She was on a half dose for the first week and started having trouble

getting to sleep. It slowly got worse during that week. When the dose

doubled in the second week all hell broke loose. By the end of the

third week she hadn't slept for 4 days/nights AT ALL. I got no

response from the doctor when I called (took him a week to ph me back)

so I decided to take her off it. It took 4 weeks until she returned to

normal. It was a terrifying experience. The doctor's comment was " Well

it's not a KNOWN side effect " Guess what? I fired him.

I look forward to hearing if anyone else has had an experience similar

to this.

Melbourne, Australia

---------------------------------

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[Guest guest]

,

I don't remember anyone here mentioning experiencing insomnia as a

side effect of sulfasalazine, but it is listed as possible side

effect:

http://www.drugs.com/sfx/sulfasalazine-side-effects.html

Not an MD

On Thu, Feb 28, 2008 at 3:53 PM, <jennyherd@...> wrote:

> Hi All

>

> Am wondering about other member's experience with Sulfasalazine

> (Salazopyrin).

>

> My daughter was put on this drug in an attempt to control a mystery

> condition (aka the doctors have NO idea what on earth is going on).

> She was on a half dose for the first week and started having trouble

> getting to sleep. It slowly got worse during that week. When the dose

> doubled in the second week all hell broke loose. By the end of the

> third week she hadn't slept for 4 days/nights AT ALL. I got no

> response from the doctor when I called (took him a week to ph me back)

> so I decided to take her off it. It took 4 weeks until she returned to

> normal. It was a terrifying experience. The doctor's comment was " Well

> it's not a KNOWN side effect " Guess what? I fired him.

>

> I look forward to hearing if anyone else has had an experience similar

> to this.

>

> Melbourne, Australia

[Guest guest]

Hi

Yes, I think her reaction was a rare one but certainly not a completely

unreported one! She had been tried on Dapsone ( a sulfon, which is I

think 'related to the sulfonamides ) which had caused very sudden and

severe hemolytic anemia. When we began to suspect that the Salaozopyrin

may be causing the insomnia I did some reading and found that the two

drugs were related and that insomnia could be a side effect. The immuno

hadn't even ordered the normal monitoring blood tests that should be

done when a patient is on sulfasalazine. The phrase 'Clinically unsafe'

springs to mind...

Anyway, thanks for the feed back. We are now have an appointment in June

to see yet another immuno at the Royal Melbourne Hospital. I think he is

in the research side of things. I desperaltely hope we make some

progress soon as the stress caused by my daughter's illness (2 years +

now, on top of a whole raft of other issues she has...) is not conducive

to keeping my Fibro (which is why I'm on this forum!) manageable!

[Guest guest]

,

Yes, if the side effect is listed by the manufacturer, it has been reported

during the trials or later when it reaches the market.

Here is the only case report I could find that mentions Salazopyrin and

insomnia:

Respiration. 1980;39(2):119-20.

Salazopyrin-induced eosinophilic pneumonia.

Berliner S, Neeman A, Shoenfeld Y, Eldar M, Rousso I, Kadish U, Pinkhas J.

A patient with ulcerative colitis developed eosinophilic pneumonia, sinus

tachycardia, skin rashes, headache and insomnia following treatment with

Salazopyrin. The pneumonia as well as the other side effects resolved

spontaneously following discontinuation of the drug and reappeared when

Salazopyrin was readministered.

PMID: 6104854

It's old as the hills, but interesting.

Sorry that you and your daughter are going through this. I hope the next

physician will be able to figure out what is going on.

Not an MD

> [ ] Re: sulfasalazine

>

> Hi

>

> Yes, I think her reaction was a rare one but certainly not a completely

> unreported one! She had been tried on Dapsone ( a sulfon, which is I

> think 'related to the sulfonamides ) which had caused very sudden and

> severe hemolytic anemia. When we began to suspect that the Salaozopyrin

> may be causing the insomnia I did some reading and found that the two

> drugs were related and that insomnia could be a side effect. The immuno

> hadn't even ordered the normal monitoring blood tests that should be

> done when a patient is on sulfasalazine. The phrase 'Clinically unsafe'

> springs to mind...

>

> Anyway, thanks for the feed back. We are now have an appointment in June

> to see yet another immuno at the Royal Melbourne Hospital. I think he is

> in the research side of things. I desperaltely hope we make some

> progress soon as the stress caused by my daughter's illness (2 years +

> now, on top of a whole raft of other issues she has...) is not conducive

> to keeping my Fibro (which is why I'm on this forum!) manageable!

>

>