RESEARCH - Important determinants of bone strength: beyond bone mineral density

[Guest guest]

J Clin Rheumatol. 2006 Apr;12(2):70-7.

Important determinants of bone strength: beyond bone mineral density.

Friedman AW.

Medical Clinic of Houston, 1707 Sunset Boulevard, Houston, TX 77005, USA.

afriedman@...

Osteoporosis is a systemic skeletal disorder characterized by compromised

bone strength that predisposes individuals to increased fracture risk. Bone

strength is determined by its material and structural properties. Bone

mineral density (BMD) is a useful tool for diagnosis; however, this

parameter provides information regarding only the quantity of mineral in

bone, which is only one component of bone strength. Osteoporosis treatments

have been shown to have beneficial effects on bone turnover,

microarchitecture, and/or mineralization, all of which can help account for

the reductions in fracture risk above and beyond changes in BMD. Newer

noninvasive imaging methods are being developed that assess bone strength

independent of BMD, and these methods should improve the assessment of

fracture risk and response to treatment. These imaging methods are not

currently available for routine clinical use, and therefore, clinicians need

to continue for now to rely on surrogate markers of bone fragility,

including BMD, prevalent fracture, and other important risk factors for

fracture.

PMID: 16601540

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16601540

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[Guest guest]

Wow, this is interesting - wonder when those assesment methods will be

available?

On 6/11/06, <Matsumura_Clan@...> wrote:

> J Clin Rheumatol. 2006 Apr;12(2):70-7.

>

>

> Important determinants of bone strength: beyond bone mineral density.

>

>

> Friedman AW.

>

> Medical Clinic of Houston, 1707 Sunset Boulevard, Houston, TX 77005, USA.

> afriedman@...

>

> Osteoporosis is a systemic skeletal disorder characterized by compromised

> bone strength that predisposes individuals to increased fracture risk. Bone

> strength is determined by its material and structural properties. Bone

> mineral density (BMD) is a useful tool for diagnosis; however, this

> parameter provides information regarding only the quantity of mineral in

> bone, which is only one component of bone strength. Osteoporosis treatments

> have been shown to have beneficial effects on bone turnover,

> microarchitecture, and/or mineralization, all of which can help account for

> the reductions in fracture risk above and beyond changes in BMD. Newer

> noninvasive imaging methods are being developed that assess bone strength

> independent of BMD, and these methods should improve the assessment of

> fracture risk and response to treatment. These imaging methods are not

> currently available for routine clinical use, and therefore, clinicians need

> to continue for now to rely on surrogate markers of bone fragility,

> including BMD, prevalent fracture, and other important risk factors for

> fracture.

>

> PMID: 16601540

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16601540

>

>

>

>

> Not an MD

--

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