RESEARCH - Reduction of inflammatory biomarker response by Orencia in treatment of RA

[Guest guest]

J Rheumatol. 2006 Oct 1; [Epub ahead of print]

Reduction of Inflammatory Biomarker Response by Abatacept in Treatment of

Rheumatoid Arthritis.

Weisman MH, Durez P, Hallegua D, Aranda R, Becker JC, Nuamah I, Vratsanos G,

Zhou Y, Moreland LW.

OBJECTIVE: Abatacept, a soluble selective costimulation modulator,

selectively modulates T cell activation via the CD80/CD86:CD28 costimulation

pathway. Data from a Phase II trial showed efficacy in patients with active

rheumatoid arthritis (RA) and inadequate response to methotrexate when

treated with abatacept (10 mg/kg or 2 mg/kg). To determine the mechanism of

action of abatacept, we analyzed changes in the serum levels of inflammatory

biomarkers in the patients enrolled in this trial. RESULTS: Following 12

months' treatment, serum levels of interleukin 6 (IL-6), soluble IL-2

receptor, C-reactive protein, soluble E-selectin, and soluble intercellular

adhesion molecule-1 were significantly lower in patients receiving abatacept

10 mg/kg versus placebo. Smaller reductions in tumor necrosis factor-a and

rheumatoid factor were also observed in the abatacept 10 mg/kg group

compared with the placebo group. Although there was no evidence for efficacy

of the 2 mg/kg dose, small reductions in inflammatory biomarkers at this

dosage support the biologic effect of this therapy.

CONCLUSION: These findings reveal the antiinflammatory and immunomodulatory

effects of abatacept in patients with RA, and are consistent with the

concept that modulating T cell activation improves clinical signs and

symptoms and inhibits the progression of structural damage. These data

suggest that selective modulation of the CD80/CD86:CD28 pathway with

abatacept may affect several inflammatory cell types and cytokines that are

involved in the proinflammatory cascade.

PMID: 17014006

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

7014006

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org