RESEARCH - Acute, chronic, and recurrent varicella zoster virus neuropathy without zoster rash

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Acute, chronic, and recurrent varicella zoster virus neuropathy without

zoster rash.

Fox RJ, Galetta SL, Mahalingam R, Wellish M, Forghani B, Gilden DH.

Department of Neurology, University of Pennsylvania School of Medicine,

Philadelphia, USA.

The authors report three patients with acute, chronic, and recurrent

neuropathy associated with varicella zoster virus (VZV) infection but

without zoster rash. CSF of all three patients contained VZV immunoglobulin

G antibody, but not herpes simplex virus. In two patients, serum/CSF ratios

of VZV immunoglobulin G were reduced compared to normal ratios for

immunoglobulin G and albumin, and one patient also had VZV immunoglobulin M

in CSF. All three patients received antiviral therapy and improved. The

diagnosis of nervous system infection by VZV may be confirmed by the

presence of antibody to VZV in CSF even without detectable VZV DNA.

PMID: 11468330

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=11468330 & itool=iconabstr & query_hl=33 & itool=pubmed_DocSum

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