RESEARCH - Cardiovascular disease and risk factors in patients with RA, PsA, and AS

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Journal of Rheumatology

November 2006

Cardiovascular Disease and Risk Factors in Patients with Rheumatoid

Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis

CHENGLONG HAN, DON W. ROBINSON Jr, MONICA V. HACKETT, L. CLARK PARAMORE,

KATHY H. FRAEMAN, and MOHAN V. BALA

ABSTRACT.

Objective. To compare the prevalence of cardiovascular diseases and their

risk factors between patients with rheumatoid arthritis (RA), psoriatic

arthritis (PsA), and ankylosing spondylitis (AS) and control subjects.

Methods. Data for patients continuously enrolled in an integrated outcomes

database between January 1, 2001, and December 31, 2002, with International

Classification of Diseases, 9th Revision codes of 714.x (RA), 696.0 (PsA),

or 720.0 (AS) were evaluated in this cross-sectional comparative study.

Control groups were established for each patient group (1:4 ratio) by

matching on the basis of age, sex, geographic region, and length of time in

plan. Age- and sex-adjusted prevalence of cardiovascular comorbidities and

risk factors were calculated; the prevalence ratio of the comorbidities and

risk factors for the patient groups compared with the control population

were estimated. Use of selected cardiovascular medications was also compared

between patient and control groups.

Results. The RA, PsA, and AS cohorts comprised 28,208, 3066, and 1843

patients, respectively. The prevalence ratio of ischemic heart disease (1.5,

1.3, 1.2), atherosclerosis (1.9, 1.4, 1.5), peripheral vascular disease

(2.4, 1.6, 1.6), congestive heart failure (2.0, 1.5, 1.8), cerebrovascular

disease (1.6, 1.3, 1.7), type II diabetes (1.4, 1.5, 1.2), hyperlipidemia

(1.2, 1.2, 1.2), and hypertension (1.3, 1.3, 1.3) were higher in patients

than controls. For RA, PsA, and AS, use of angiotensin-converting enzyme

inhibitors, calcium channel blockers, diuretics, nitrates/vasodilators,

anticoagulants, and antihyperlipidemia agents was significantly higher in

patients than controls.

Conclusion. Cardiovascular diseases and their risk factors were more common

in patients with RA, PsA, and AS than in matched controls. (First Release

Sept 15 2006; J Rheumatol 2006;33:2167-72)

http://www.jrheum.com/abstracts/abstracts06/2167.html

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