CASE REPORTS - The role of parotid biopsy in the diagnosis of pediatric Sjogren syndrome

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Arch Otolaryngol Head Neck Surg. 2002 Nov;128(11):1279-81.

The role of parotid biopsy in the diagnosis of pediatric Sjogren syndrome.

McGuirt WF Jr, Whang C, Moreland W.

Department of Otolaryngology, Wake Forest University Baptist Medical Center,

Winston-Salem, NC 27157-1034, USA.

OBJECTIVES: To describe our experience with primary and secondary Sjogren

syndrome (SS) in the pediatric population and to evaluate the effectiveness

of parotid gland biopsy in the diagnosis of pediatric SS. DESIGN: Case

series review of 6 pediatric patients evaluated during a 4-year period with

varied head and neck manifestations of SS. SETTING: Tertiary care children's

hospital. PATIENTS: Six children (4 boys and 2 girls) ranging in age from 6

to 12 years, who were diagnosed as having primary or secondary SS.

INTERVENTION: Six minor salivary gland and 4 parotid gland biopsies for

pathologic examination. MAIN OUTCOME MEASURES: Pathologic examination of

salivary tissue consistent with SS. RESULTS: All 6 patients underwent minor

salivary gland biopsy, 2 (33%) were consistent with SS, while the remaining

4 (67%) were nondiagnostic. The 4 patients with nondiagnostic minor salivary

gland biopsy results went on to have parotid biopsies, of which all 4 had

histologic findings consistent with SS. No complications were encountered.

CONCLUSION: Parotid gland biopsy is an effective and safe means of obtaining

salivary gland tissue for histologic evaluation of SS in the pediatric

population.

PMID: 12431170

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12431170

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