REVIEW - Musculoskeletal manifestations and autoimmune diseases related to new biologic agents

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Curr Opin Rheumatol. 2006 Jan;18(1):96-100.

Musculoskeletal manifestations and autoimmune diseases related to new

biologic agents.

Haraoui B, Keystone E.

Universite de Montreal, RDU CHUM, Hopital Notre-Dame, Montreal, Quebec,

Canada. paulharaoui@...

PURPOSE OF REVIEW: The anti-tumor necrosis factor agents are now widely used

in the management of patients with rheumatoid arthritis, ankylosing

spondylitis, psoriatic arthritis and juvenile inflammatory arthritis. One of

the most common observations made during their use is the development of

autoantibodies. The purpose of this paper is to review this phenomenon and

its clinical implications. RECENT FINDINGS: While the development of

different autoantibodies is a common encounter, rare cases of lupus-like

syndromes have been reported. On the other hand, a variety of

immune-mediated clinical manifestations have been described, including

vasculitis and demyelinating syndromes. Rare cases of cytopenia and

non-specific lung injuries have also been reported.

SUMMARY: While these clinical complications are rare and isolated events,

clinicians must be aware of their occurrence. The experience with the

anti-tumor necrosis factor agents is rather short and new, unusual

immune-mediated complications may still appear. Clinicians should be

prepared to recognize them.

PMID: 16344625

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6344625

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