CASE REPORT - Sjogren syndrome in a child: favorable response of the arthritis to TNF-alpha blockade

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Clin Rheumatol. 2006 Jan 4;:1-3 [Epub ahead of print]

Sjogren syndrome in a child: favorable response of the arthritis to TNFalpha

blockade.

Pessler F, Monash B, Rettig P, Forbes B, Kreiger PA, Cron RQ.

Division of Rheumatology, Department of Pediatrics, The Children's Hospital

of Philadelphia, 3405 Civic Center Boulevard, Philadelphia, 19104, PA, USA,

pessler@....

Tumor necrosis factor alpha (TNFalpha) blockade has recently been found to

be ineffective in treating glandular and extraglandular manifestations of

adult Sjogren syndrome (SS), including arthralgia and arthritis. We report a

girl who developed purpura, polyarthritis, uveitis, and severe dental caries

in the first year of life and optic neuritis by age three. SS was diagnosed

at 11 years of age, when severe hypokalemic renal tubular acidosis developed

during infliximab treatment for arthritis. In contrast to her other disease

manifestations, the arthritis responded remarkably well to TNFalpha

blockade, suggesting that TNFalpha blockers may have a role in the treatment

of arthritis with pediatric SS.

PMID: 16391885

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16391885

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