RESEARCH - Diagnostic and predictive value of anti-CCP antibodies in RA: a systemic literature review

[Guest guest]

Ann Rheum Dis. 2006 Jul;65(7):845-51. Epub 2006 Apr 10.

Diagnostic and predictive value of anti-cyclic citrullinated protein

antibodies in rheumatoid arthritis: a systematic literature review.

Rene Descartes University, Medicine Faculty, and APHP Cochin Hospital,

Rhumatologie B Department, Paris, France.

OBJECTIVE: To evaluate the two generations of anti-cyclic citrullinated

protein (CCP) antibodies as a diagnostic marker of rheumatoid arthritis (RA)

and as a predictor of future development of RA in healthy subjects and in

patients with early undifferentiated arthritis. METHODS: A systematic

analysis of the literature published between 1999 and February 2006 was

conducted. Data were collected on the sensitivity and specificity of the two

generations of anti-CCP antibodies for diagnosing RA and predicting future

development of the disease. RESULTS: Among 107 studies initially identified,

68 had interpretable data and were analysed. Diagnostic properties were

assessed in 58 studies: mean (SD) sensitivity was 53 (10)% (range 41-68) and

68 (15)% (range 39-94) for anti-CCP1 and anti-CCP2, respectively; mean (SD)

specificity was 96 (3)% (range 90-99) and 95 (5)% (range 81-100) for

anti-CCP1 and anti-CCP2, respectively. Predictive properties were assessed

in 14 studies; odds ratio (95% confidence interval) of anti-CCP1 and

anti-CCP2 for the future development of RA were 20 (14 to 31) and 25 (18 to

35), respectively, among patients with early undifferentiated arthritis and

64.5 (8.5 to 489) and 28 (8 to 95), respectively, among healthy subjects.

CONCLUSION: Sensitivity of the second generation of anti-CCP is close to

that of rheumatoid factor, with a higher specificity, for distinguishing RA

from other rheumatic diseases. Moreover, anti-CCP antibodies appear to be

highly predictive of the future development of RA in both healthy subjects

and patients with undifferentiated arthritis.

PMID: 16606649

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=16606649

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org