Mercury Containing Preservative Alters Immune Function

[Guest guest]

NAA -you rock! Cregar <diana.cregar@...> wrote: Study: Thimerosal disrupts dendritic cellsDAVIS, Calif., March 21 (UPI)http://www.upi.com/NewsTrack/view.php?StoryID=20060321-042435-6981rWed, Mar. 22, 2006Vaccine study findings fuel debate over autismBy SANDY KLEFFMANContra CostaTimes (Walnut Creek, Calif.)http://www.kansascity.com/mld/kansascity/news/breaking_news/14158848.htmMercury Containing Preservative Alters Immune FunctionBy Neil Osterweil, Senior Associate Editor, MedPage TodayMarch 21, 2006http://www.medpagetoday.com/InfectiousDisease/Vaccines/tb/2900Thimerosal linked with immune system dysfunction in miceBy University of California, - Health SystemMar 21, 2006, 01:53http://www.foodconsumer.org/777/8/Thimerosal_linked_with_immune_system_dysfunction_in_mice.shtmlStudy with Mice Links Thimerosal with Immune System DysfunctionNewswise (press release) - Mar 20, 2006Newswise — A team of cell biologists, toxicologists and molecularbioscientists at UC has published a study connecting thimerosal withdisruptions in ...National Autism Association Supports Congressional Action to ... News (press release) - Mar 20, 2006NIXA, Mo., March 20 /PRNewswire/ -- The National Autism Association (NAA)today expressed support for a

Congressional request that the NationalInstitute of ...Study: Vaccine can disrupt immune systemThe Argus, CA - 51 minutes agoBy Dorsey Griffith, SCRIPPS McCLATCHY NEWS SERVICE. SACRAMENTO — In a studysure to fuel the controversy about the role of childhood ...Thimerosal linked to immune system illsScripps News Service, DC - 2 hours agoBy DORSEY GRIFFITH. In a study sure to fuel the controversy about the roleof childhood vaccines in autism, scientists have found ...Study: Thimerosal disrupts dendritic cellsNewKerala.com, India - 12 hours agoDAVIS, Calif.: A team of University of California- scientists haslinked thimerosal with disruptions in antigen-presenting cells known asdendritic cells. ...National Autism Association backs inquiry into vaccine/autism linkPharmaceutical Business Review - 15 hours agoBy Staff Writer. The National Autism Association has expressed support for aUS

Congressional request that the National Institute ...National Autism Association Backs Inquiry into Vaccine/Autism LinkInternational News Service, Australia - 15 hours agoThe National Autism Association has expressed support for a US Congressionalrequest that the National Institute of Environmental Health Sciences conduct...Study: Thimerosal Disrupts Dendritic CellsPost Chronicle - 16 hours agoby UPI Wire. DAVIS, Calif. - March 21, 2006 (UPI) -- A team of University ofCalifornia- scientists has linked thimerosal with ...UC Study With Mice Links Thimerosal With Immune System ...Medical News Today (press release), UK - 17 hours agoA team of cell biologists, toxicologists and molecular bioscientists at theUniversity of California, , has published a study connecting thimerosalwith ...Study: Thimerosal disrupts dendritic cellsDailyIndia.com, NY - 20 hours agoDAVIS, Calif. (UPI) -- A team

of University of California- scientistshas linked thimerosal with disruptions in antigen-presenting ...National Autism Association Supports Congressional Action to ...PR Newswire (press release), NY - Mar 20, 2006Congress urges inquiry into injuries from mercury-containing vaccines as CDCrecommends additional mercury exposure through aggressive flu vaccineschedule for ...

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[Guest guest]

How about those trace amounts? What are they in ppb, etc. If you

are still giving the DPaT,Hib and Hep B with their trace amounts on

one day aren't you still causing damage. Is there anyone monitoring

these trace amounts? All it takes is one young chemical engineer

with a great cost savings idea to turn off the distillation column

at any time. Holly

Study: Thimerosal disrupts

dendritic cells

> DAVIS, Calif., March 21 (UPI)

>

> http://www.upi.com/NewsTrack/view.php?StoryID=20060321-042435-6981r

>

> Wed, Mar. 22, 2006

> Vaccine study findings fuel debate over autismBy SANDY

KLEFFMANContra Costa

> Times (Walnut Creek, Calif.)

>

>

http://www.kansascity.com/mld/kansascity/news/breaking_news/14158848.

htm

>

> Mercury Containing Preservative Alters Immune Function

> By Neil Osterweil, Senior Associate Editor, MedPage Today

> March 21, 2006

>

> http://www.medpagetoday.com/InfectiousDisease/Vaccines/tb/2900

>

>

> Thimerosal linked with immune system dysfunction in mice

> By University of California, - Health System

> Mar 21, 2006, 01:53

>

>

http://www.foodconsumer.org/777/8/Thimerosal_linked_with_immune_syste

m_dysfu

> nction_in_mice.shtml

>

>

> Study with Mice Links Thimerosal with Immune System Dysfunction

> Newswise (press release) - Mar 20, 2006

> Newswise — A team of cell biologists, toxicologists and molecular

> bioscientists at UC has published a study connecting

thimerosal with

> disruptions in ...

>

> National Autism Association Supports Congressional Action to ...

> News (press release) - Mar 20, 2006

> NIXA, Mo., March 20 /PRNewswire/ -- The National Autism

Association (NAA)

> today expressed support for a Congressional request that the

National

> Institute of ...

>

> Study: Vaccine can disrupt immune system

> The Argus, CA - 51 minutes ago

> By Dorsey Griffith, SCRIPPS McCLATCHY NEWS SERVICE. SACRAMENTO —

In a study

> sure to fuel the controversy about the role of childhood ...

>

> Thimerosal linked to immune system ills

> Scripps News Service, DC - 2 hours ago

> By DORSEY GRIFFITH. In a study sure to fuel the controversy about

the role

> of childhood vaccines in autism, scientists have found ...

>

> Study: Thimerosal disrupts dendritic cells

> NewKerala.com, India - 12 hours ago

> DAVIS, Calif.: A team of University of California- scientists

has

> linked thimerosal with disruptions in antigen-presenting cells

known as

> dendritic cells. ...

>

> National Autism Association backs inquiry into vaccine/autism link

> Pharmaceutical Business Review - 15 hours ago

> By Staff Writer. The National Autism Association has expressed

support for a

> US Congressional request that the National Institute ...

>

> National Autism Association Backs Inquiry into Vaccine/Autism Link

> International News Service, Australia - 15 hours ago

> The National Autism Association has expressed support for a US

Congressional

> request that the National Institute of Environmental Health

Sciences conduct

> ...

>

> Study: Thimerosal Disrupts Dendritic Cells

> Post Chronicle - 16 hours ago

> by UPI Wire. DAVIS, Calif. - March 21, 2006 (UPI) -- A team of

University of

> California- scientists has linked thimerosal with ...

>

> UC Study With Mice Links Thimerosal With Immune System ...

> Medical News Today (press release), UK - 17 hours ago

> A team of cell biologists, toxicologists and molecular

bioscientists at the

> University of California, , has published a study connecting

thimerosal

> with ...

>

> Study: Thimerosal disrupts dendritic cells

> DailyIndia.com, NY - 20 hours ago

> DAVIS, Calif. (UPI) -- A team of University of California-

scientists

> has linked thimerosal with disruptions in antigen-presenting ...

>

> National Autism Association Supports Congressional Action to ...

> PR Newswire (press release), NY - Mar 20, 2006

> Congress urges inquiry into injuries from mercury-containing

vaccines as CDC

> recommends additional mercury exposure through aggressive flu

vaccine

> schedule for ...

>

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

Thimersaol disrupts all cells with receptors for immune complexes including glial

cells in the brain , thus causing the memory loss of autism, CFIDS, Gulf War

Illness, Sheepherders disease and Alzheimer's Dis., and the mesangial cells of the reinal vessels

in retinitis pigmentosa,

the ileal lymph node dendritic cells in infantile regional ilietis.<

From: " Cregar" <diana.cregar@...>Reply-EOHarm To: <EOHarm >Subject: Mercury Containing Preservative Alters Immune FunctionDate: Wed, 22 Mar 2006 13:02:11 -0500Study: Thimerosal disrupts dendritic cellsDAVIS, Calif., March 21 (UPI)http://www.upi.com/NewsTrack/view.php?StoryID=20060321-042435-6981rWed, Mar. 22, 2006Vaccine study findings fuel debate over autismBy SANDY KLEFFMANContra CostaTimes (Walnut Creek, Calif.)http://www.kansascity.com/mld/kansascity/news/breaking_news/14158848.htmMercury Containing Preservative Alters Immune FunctionBy Neil Osterweil, Senior Associate Editor, MedPage TodayMarch 21, 2006http://www.medpagetoday.com/InfectiousDisease/Vaccines/tb/2900Thimerosal linked with immune system dysfunction in miceBy University of California, - Health SystemMar 21, 2006, 01:53http://www.foodconsumer.org/777/8/Thimerosal_linked_with_immune_system_dysfunction_in_mice.shtmlStudy with Mice Links Thimerosal with Immune System DysfunctionNewswise (press release) - Mar 20, 2006Newswise — A team of cell biologists, toxicologists and molecularbioscientists at UC has published a study connecting thimerosal withdisruptions in ...National Autism Association Supports Congressional Action to ... News (press release) - Mar 20, 2006NIXA, Mo., March 20 /PRNewswire/ -- The National Autism Association (NAA)today expressed support for a Congressional request that the NationalInstitute of ...Study: Vaccine can disrupt immune systemThe Argus, CA - 51 minutes agoBy Dorsey Griffith, SCRIPPS McCLATCHY NEWS SERVICE. SACRAMENTO — In a studysure to fuel the controversy about the role of childhood ...Thimerosal linked to immune system illsScripps News Service, DC - 2 hours agoBy DORSEY GRIFFITH. In a study sure to fuel the controversy about the roleof childhood vaccines in autism, scientists have found ...Study: Thimerosal disrupts dendritic cellsNewKerala.com, India - 12 hours agoDAVIS, Calif.: A team of University of California- scientists haslinked thimerosal with disruptions in antigen-presenting cells known asdendritic cells. ...National Autism Association backs inquiry into vaccine/autism linkPharmaceutical Business Review - 15 hours agoBy Staff Writer. The National Autism Association has expressed support for aUS Congressional request that the National Institute ...National Autism Association Backs Inquiry into Vaccine/Autism LinkInternational News Service, Australia - 15 hours agoThe National Autism Association has expressed support for a US Congressionalrequest that the National Institute of Environmental Health Sciences conduct...Study: Thimerosal Disrupts Dendritic CellsPost Chronicle - 16 hours agoby UPI Wire. DAVIS, Calif. - March 21, 2006 (UPI) -- A team of University ofCalifornia- scientists has linked thimerosal with ...UC Study With Mice Links Thimerosal With Immune System ...Medical News Today (press release), UK - 17 hours agoA team of cell biologists, toxicologists and molecular bioscientists at theUniversity of California, , has published a study connecting thimerosalwith ...Study: Thimerosal disrupts dendritic cellsDailyIndia.com, NY - 20 hours agoDAVIS, Calif. (UPI) -- A team of University of California- scientistshas linked thimerosal with disruptions in antigen-presenting ...National Autism Association Supports Congressional Action to ...PR Newswire (press release), NY - Mar 20, 2006Congress urges inquiry into injuries from mercury-containing vaccines as CDCrecommends additional mercury exposure through aggressive flu vaccineschedule for ...

[Guest guest]

Herman,

I have ben reading an immunology book. Am I to understand that there

are receptors for immune function ,that can become blocked? If so

could it be that the kids who have done well on gammaglobulin or

transferefactor[taking 10 steps forward on the therapy, and 5 steps

back off it] need a maintinance dose? Will they need this for life so

that thier cells communicate properly?

Regarding saccharomyces cerivisiae[beta glucan] How can we break that

cell wall and kill it? I know that saccharomyces and e-coli have dna

sex, and thus create a new problem for us. Do you know any way to

remove it, when it was the first substance introduced into the infant

body, even before breast milk? Or is it concidered self by the body?

Sorry to be so long,

Thankyou for all your help,

Dot

[Guest guest]

Herman, I noticed you stated thimerosol disrupts,not destroys the

cells.Does this mean the cells CAN BE REPAIRED? Also, the Hep B my

child was given was a recombinant DNA vaccine made with genetically

modified yeast(saccharomyes cerevisiae).Do you know what the modify

with? I have suspected for years that this caused him to have an auto-

immune response to a virus being introduced in a yeast base that was

NOT completely removed(the PDR states that 1 % was possibly left in).

Also,this vaccine caused lots of peptides in the childs body to

converge on each cell containing the virus.Did that mean he was and

still could be depleted of amino acids?If I give him aminos does that

mean the virus will proliferate more? Thanks for any help,

[Guest guest]

Mercury Containing Preservative Alters Immune Function



By Neil Osterweil, Senior Associate Editor, MedPage Today

Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University

of Pennsylvania School of Medicine.

March 21, 2006



MedPage Today Action Points

Explain to interested patients that this study suggests that

thimerosal can interfere with the cell-signaling and development of

dendritic cells, key immune system cells that activate T-cells as

part of the immune response.

Caution patients that this study does not purport to show any link

between the presence of thimerosal in vaccines and the development of

autism or other developmental disorders.

Review

DAVIS, Calif., March 21 - Thimerosal, a mercury-containing organic no

longer used as a preservative in many pediatric vaccines, can disrupt

certain antigen presenting cells and may affect the immune response

to external factors, reported investigators here.

Although far from the smoking gun that proponents of a thimerosal-

autism link seek, the finding suggested that thimerosal exposure

could cause dendritic cells to activate " aberrant and harmful immune

responses, " according to Isaac N. Pessah, Ph.D., and colleagues of

the University of California at . They reported the research

online in Environmental Health Perspectives.

" This is the first time that thimerosal has been shown to selectively

alter the normal functions of dendritic cells, " said Dr. Pessah, a

toxicologist and director of the Children's Center for Environmental

Health and Disease Prevention at Cal .

He added that dendritic cells " play pivotal roles in overcoming viral

and bacterial invaders by coordinating the immune system's overall

combat response. "

Yet, Dr. Pessah emphasized, " Our findings do not directly implicate

thimerosal as a single causative agent for triggering

neurodevelopmental disorders such as autism. "

" There is growing evidence that autism is several disorders that we

now refer to as just one, " he added. " There is also growing evidence

that some children with autism have unique immune cell composition

and responses to antigens. The results of our work provide a

framework to test the hypothesis that the genetic background of some

individuals may render them especially susceptible to thimerosal. "

Dendritic cells are antigen-presenting cells that are potent

activators of T-cells. But as Dr. Pessah and colleagues demonstrated

in their study of cultured mouse cells, exposure to thimerosal

disrupts calcium-channel signaling within dendritic cells, thereby

altering growth patterns, maturation, and activation.

They determined this by exposing both mature and immature dendritic

cells cultured from murine bone marrow to thimerosal at varying

concentrations. The authors used immunocytofluorescence to visualize

the effect of thimerosal exposure on calcium channels. Thimerosal

contains approximately 50% ethylmercury by weight.

They found that at concentrations of 20 parts per billion, exposure

of the dendritic cells to thimerosal altered the normal cross-talk

between the calcium channels RyR12 and IP3R1, thereby " garbling the

normal signaling system between them. "

In addition, exposure to the compound resulted in irregular secretion

by the dendritic cells of the pro-inflammatory cytokine interleukin-6.

When they ramped up thimerosal concentrations to 200 parts per

billion, they found that it induced apoptosis of dendritic cells

before they had fully matured, thereby preventing T-cell activation.

The finding suggests that in addition to its known neurotoxic

properties, ethylmercury may also be an immunotoxicant, the authors

said.

" A practical implication of the present findings has relevance to the

commercial uses of thimerosal as an antimicrobial agent in vaccines

and consumer products since they identify dendritic cells as

sensitive targets for thimerosal and ethylmercury-mediated

dysfunction, " they wrote. " Given the importance of dendritic cells as

a front line in regulating lymphocyte mediated immunity and

tolerance, altering dendritic cell functions by forms of ethylmercury

should be considered when assessing contributions to altered immune

function. "

They stopped short, however, of fingering thimerosal as a cause of

autism. Thimerosal is still used in some commercial vaccines.

Other experts also advised drawing no final conclusions regarding

thimerosal and autism on the basis of on this research.

" These findings should be interpreted cautiously. Although they

suggest that thimerosal may affect dendritic cell function, the

pathophysiological consequences of thimerosal remain unclear, " said

A. Schwartz, M.D., director of the National Institute of

Environmental Health Sciences, who was not involved in the study.



Primary source: Environmental Health Perspectives

Source reference:

Goth SR et al. Uncoupling of ATP-mediated Calcium Signaling and

Dysregulated IL-6 Secretion in Dendritic Cells by Nanomolar

Thimerosal Environmental Health Perspectives. doi:10.1289/ehp.8881

http://www.medpagetoday.com/InfectiousDisease/Vaccines/tb/2900#