RESEARCH - Inflammatory and hormonal measures predict neuropsychological functioning in SLE and RA

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J Int Neuropsychol Soc. 2001 Sep;7(6):745-54. Links

Inflammatory and hormonal measures predict neuropsychological functioning in

systemic lupus erythematosus and rheumatoid arthritis patients.

National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

KozoraE@...

Abnormalities of inflammatory and hormonal measures are common in SLE

patients. Although cognitive dysfunction has been documented in SLE

patients, the biological mechanism of these deficits has not been clarified.

The goal of this study was to explore the relationship between inflammatory

and hormonal activity and measures of learning, fluency, and attention in

systemic lupus erythematosus patients without neuropsychiatric symptoms

(non-CNS-SLE), patients with rheumatoid arthritis (RA), and healthy controls

(HC). Fifteen non-CNS-SLE patients, 15 RA patients and 15 HC participants

similar in age, education, and gender (female) were compared on tests of

cognition, depression, and plasma levels of interleukin-6 (IL-6),

dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and

cortisol. Non-CNS-SLE patients demonstrated lower learning and poorer

attention. Furthermore, non-CNS-SLE and RA patients had significantly lower

levels of DHEA and DHEA-S than HC participants. Hierarchical regression

analysis demonstrates that DHEA-S and IL-6 accounts for a unique portion of

the variance in subject performance on measures of learning and attention

after controlling for depression and corticosteroid treatment. This data

highlights the value of hierarchical analyses with covariates, and provides

evidence in humans of a relationship between peripheral cytokine levels and

cognitive function.

PMID: 11575596

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=11575596

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