RESEARCH - Aged garlic extract protects against MTX-induced apoptotic cell injury of IEC-6 cells

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© 2006 American Society for Nutrition J. Nutr. 136:861S-863S, March 2006

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Supplement: Significance of Garlic and Its Constituents in Cancer and

Cardiovascular Disease

Aged Garlic Extract Protects against Methotrexate-Induced Apoptotic Cell

Injury of IEC-6 Cells1,2

Gastrointestinal toxicity is one of the most serious side effects of

methotrexate (MTX) treatment. The side effects often disrupt the cancer

chemotherapy. We previously reported that aged garlic extract (AGE) protects

the small intestine of rats from MTX-induced damage. In this study, the

protection of AGE against MTX-induced damage of IEC-6 cells originating from

the rat jejunum crypt was investigated. MTX decreased the viability of IEC-6

cells, but this effect was prevented by AGE (0.5%). The MTX-induced

apoptosis of IEC-6 cells was depressed by AGE. These results indicated that

AGE protects IEC-6 cells from the MTX-induced damage. AGE may be useful in

cancer chemotherapy with MTX because it reduces MTX-induced intestinal

damage.

http://www.nutrition.org/cgi/content/abstract/136/3/861S

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