RESEARCH - Anti-TNF-induced psoriasis

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J Rheumatol. 2006 Jul;33(7):1411-4.

Anti-tumor necrosis factor-alpha-induced psoriasis.

Sari I, Akar S, Birlik M, Sis B, Onen F, Akkoc N.

Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul

University School of Medicine, Izmir, Turkey.

We describe a patient with rheumatoid arthritis who developed psoriasis

during treatment with etanercept; psoriatic lesions resolved completely

after the drug was discontinued, but returned on rechallenge. No such

adverse skin reaction occurred after switching therapy to infliximab.

Through a Medline search we identified 11 reports involving 32 patients who

developed psoriasis/psoriasiform eruptions during therapy with tumor

necrosis factor-alpha (TNF-alpha) inhibitors. All TNF-alpha blocking agents

have been reported to lead to or exacerbate psoriasis. In some cases skin

changes were severe enough to discontinue the medication.

PMID: 16821276

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6821276

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