RESEARCH - Comparative analysis of autoantibodies against a-fodrin in Sjogren's syndrome

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J Rheumatol. 2006 Jul;33(7):1289-92.

Comparative analysis of autoantibodies against a-fodrin in serum, tear

fluid, and saliva from patients with Sjogren's syndrome.

Yavuz S, Toker E, Bicakcigil M, Mumcu G, Cakir S.

Department of Rheumatology, and the Faculties of Health Education,

University of Marmara Medical School, Istanbul, Turkey. suleyavuz@...

OBJECTIVE: To evaluate levels of IgA and IgG antibodies against a-fodrin in

serum, tear fluid, and saliva and compare them with anti-Ro and anti-La

antibody levels in the same samples of patients with Sjogren's syndrome

(SS). METHODS: Samples from 25 patients with SS (17 primary and 8

secondary), 8 patients with systemic lupus erythematosus (SLE), and 7

patients with rheumatoid arthritis (RA) as well as 20 healthy blood donor

controls were collected. Antibodies were measured using ELISA. RESULTS:

Although 40% of patients with primary SS had IgG anti-a-fodrin in their

sera, it was also found in 36% and 32% of samples of their tear fluid and

saliva, respectively. IgA a-fodrin antibodies were detected in 32% of SS

sera, 20% of tear fluid samples, and 32% of saliva samples. Although the

level of IgG anti-a-fodrin was significantly greater in serum, tear fluid,

and saliva of SS patients compared to controls (p < 0.001), a significant

difference was observed only in serum and saliva. While anti-Ro was detected

in 48%, 56%, and 24% of serum, tear fluid, and saliva samples, respectively,

anti-La was found in 40%, 44%, and 28%. Significant association was observed

between serum IgG antibodies against a-fodrin and dry eye symptom score and

rose bengal staining score. A negative association was also noted between

tear IgA antibodies against a-fodrin and Schirmer I test.

CONCLUSION: Correlation of IgG and IgA antibodies against a-fodrin with the

severity of eye involvement suggests that these autoantibodies may be

considered activation markers of SS.

PMID: 16821267

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6821267

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