CASE REPORTS - Skin ulceration after Arava treatment in two patients with RA

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Journal der Deutschen Dermatologischen Gesellschaft

Volume 4 Page 324 - April 2006

Skin ulceration after leflunomide treatment in two patients with

rheumatoid arthritis

Leflunomide is a disease-modifying antirheumatic drug for the

treatment of active rheumatoid arthritis and psoriatic arthritis. Skin

ulcerations are not listed as a side effect for this drug, and there has

been only one case report on leflunomide associated skin ulcerations. We

report on two females, 59 and 63 years old respectively, who were treated

with leflunomide for rheumatoid arthritis and subsequently developed severe

skin ulcerations. After discontinuation of the drug the skin ulcerations

healed complete even if very slowly.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1610-0387.2006.05934.x

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Mayo Clinic in Rochester

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s Hopkins Medicine

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