RESEARCH - Helicobacter pylori-associated immune thrombocytopenia

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Platelets. 2006 Mar;17(2):71-7.

Helicobacter pylori-associated immune thrombocytopenia.

Franchini M, Veneri D.

Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona,

Verona, Italy. mfranchini@...

Idiopathic thrombocytopenic purpura (ITP), a disorder characterized by

autoantibody-mediated platelet destruction, may be primary or secondary to

various illnesses including lymphoproliferative, autoimmune, or infectious

diseases. There are increasing data on the association between Helicobacter

pylori infection and idiopathic thrombocytopenic purpura and the significant

increase in platelet count after bacterial eradication. The aim of this

review is to consider the studies so far published on Helicobacter pylori

infection and idiopathic thrombocytopenic purpura in order to evaluate a

possible pathogenic correlation between these two conditions. A review of

the literature data show that Helicobacter pylori eradication in patients

with idiopathic thrombocytopenic purpura is effective in increasing platelet

count in approximately half of the cases. However, since the studies so far

published are few, sometimes controversial and involve small series of

patients, further controlled studies on larger numbers of patients with

longer follow-up are needed to confirm these preliminary findings.

PMID: 16421007

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16421007

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