Re: INFO - More on Arava (leflunomide) persistence/clearance

[Guest guest]

Do you know what this would translate to for a 3 week use--no loading

dose. (Can't recall the dose, but it was the standard given.)

Sierra

--- In , " " <Matsumura_Clan@...>

wrote:

>

> Clinical Geriatrics

> " Management of Rheumatoid Arthritis in the Elderly "

>

>

> Excerpt:

>

> " Leflunomide is a pro-drug that undergoes hepatic metabolism in the

liver to

> an active metabolite, A77 1726, two-thirds of which is excreted by

the gut

> and one-third by the kidney. The half-life of leflunomide is rather

long,

> about 15 days. In addition, the drug undergoes continuous

enterohepatic

> recirculation. Leflunomide levels will therefore remain for many

months

> after the medication is stopped. The drug can be efficiently

removed from

> circulation with the addition of the resin cholestyramine, which

binds

> leflunomide in the gut, causing elimination in the stool. "

>

>

> http://www.hmpcommunications.com/cg/displayArticle.cfm?

articleID=cgac547

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

[Guest guest]

Interesting! Thank you. I have had some intermittent pain return over

the past week. I'm reintroducing foods after a 25-day elimination

diet, so it may be due to that. (I had dramatic allergic reactions to

eggs and wheat--even had to go buy Benedryl after eating the eggs. I

ached all over after eating wheat. Tonight I sneezed repeatedly while

standing near the flour in the grocery store.) It may be true that

more of the Arava has cleared and symptoms are returning. I'll

observe a bit longer and if the RA is becoming active again, my next

step is to start the sulphasalazine.

Sierra

> >>

> >> Clinical Geriatrics

> >> " Management of Rheumatoid Arthritis in the Elderly "

> >>

> >>

> >> Excerpt:

> >>

> >> " Leflunomide is a pro-drug that undergoes hepatic metabolism in

the

> > liver to

> >> an active metabolite, A77 1726, two-thirds of which is excreted

by

> > the gut

> >> and one-third by the kidney. The half-life of leflunomide is

rather

> > long,

> >> about 15 days. In addition, the drug undergoes continuous

> > enterohepatic

> >> recirculation. Leflunomide levels will therefore remain for many

> > months

> >> after the medication is stopped. The drug can be efficiently

> > removed from

> >> circulation with the addition of the resin cholestyramine, which

> > binds

> >> leflunomide in the gut, causing elimination in the stool. "

> >>

> >>

> >> http://www.hmpcommunications.com/cg/displayArticle.cfm?

> > articleID=cgac547

> >>

> >>

> >>

> >>

>