RESEARCH - Maternal smoking in pregnancy as a determinant of RA and other IPs during the first 7 years of life

[Guest guest]

Int J Epidemiol. 2005 Jun;34(3):664-71. Epub 2005 Jan 13.

Maternal smoking in pregnancy as a determinant of rheumatoid arthritis and

other inflammatory polyarthropathies during the first 7 years of life.

Jaakkola JJ, Gissler M.

Institute of Occupational and Environmental Medicine, The University of

Birmingham, Edgbaston, Birmingham B15 2TT, UK. j.jaakkola@...

OBJECTIVES: Personal smoking and gender are determinants of adult rheumatoid

arthritis. We assessed the independent and joint effects of maternal smoking

in pregnancy and gender on the development of rheumatoid arthritis and other

inflammatory polyarthropathies (RA & IP, ICD-9 code 714) in particular

juvenile rheumatoid arthritis (JRA, ICD-9 code 714.3) in the first 7 years

of life in a cohort of Finnish children born in 1987. METHODS: We identified

58 841 singleton births from the Finnish Medical Birth Registry and

followed-up on them through other nationwide registries for 7 years. The

birth registry provided categorical information on the mother's smoking

during pregnancy: no smoking as a reference, low exposure (<10 cigarettes

per day) and high exposure (>10 cigarettes per day). RESULTS: There were 75

cases of RA & IP yielding an incidence rate of 18.5 per 100 000 person-years.

Of these, 31 were classified as JRA with an incidence rate of 7.6 per 100

000 person-years. In logistic regression, both the risks of RA & IP (adjusted

odds ratio (OR) 2.10; 95% confidence interval (CI) 1.30-3.40) and JRA (3.03;

1.36-6.76) were increased in girls. High exposure to tobacco smoke increased

the risks of RA & IP (2.57; 1.13-5.89) and JRA (2.98; 0.95-8.78) in girls, but

not in boys. The adjusted ORs for girls with heavy exposure were 4.64

(1.94-11.07) for RA & IP and 6.76 (2.00-22.9) for JRA compared with unexposed

boys.

CONCLUSION: This is an original finding of a potential effect of foetal

exposure to tobacco smoke on the risks of RA & IP and JRA in girls.

PMID: 15649961

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15649961

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org