(sert) serotonin transporter

[Guest guest]

ive started this topic to discuss the serotonin transporter (sert)

and its possible implications regarding pssd.

i think its important to gain more of an understanding about this.

all i know about this so far is that its a protein that transports

serotonin (5ht) arround the brain in and out of neurons.

i also know it has some association with neural nitric oxide.

also its this transporter that your friendly ssri binds to preventing

it going home to sleep in its nice home (the neuron).

what i want to know about this thing is how its made, what triggers

its releace from the neuron, is it constantly regenerated i.e doe it

have have a life expectancy, is it produced in the neuron, does it

under go any changes from when its released to when it re uptakes?

i know the general consensus seems to be that pssd is caused by

changes in gene expression (i think vornan shares this view).

what i know about genes is very little, but here goes- genes emit

proteins (that's it by the way) now seen as though our serotonin

transporter is a protein would it be reasonable to assume that it is

emitted by a gene or genes?

and if so is it these genes/gene expression that has changed.

if so what do we know about the genes that emit the protein

responsible for sert?

[Guest guest]

One question I'm not sure about. Does pssd oversensitize the serotonin

neurotransmitors, or make them less sensitive. I have been suffering

from symptoms of low serotonin, eg. irritable bowel syndrome, mood

swings, depression etc. I have been taking 5HTP a bit, and it seemed to

normalize my sex drive a bit. It also helpde with smooth msucles,

sensitivity etc.

I would like to know what happens on a mixture of a dopamine agonist,

some 5HTP, and maybe something to raise adrenaline and a bit of

exercise?

Still not sure I really understand the whole thing about serts?

[Guest guest]

pssd could be ether over sensitised serotonin neurons or under

sensitive.

pseudoephedrine will enhance adrenaline, so will tyrosine as well as

dopamine, with b6 & b2.

i dont understand this sert thing yet, i believe its important to

understand it though regarding pssd.

i think when you have a thought or an emotional response, the

neurotransmitter is released from a neuron it binds to a receptor

sight which allows the transmission of an electrical signal.

i think sert comes along and takes the neurotransmitter back to where

it was released, so it remembers that pathway.

the ssri binds to sert's serotonin receptor sight and stops it from

being able to take it back where it came from, so as to stimulate the

neuron for longer.

it could be this action that develops pssd in people that only take

ssris for a short amount of time, especially if they were engaging in

a lot of sex while on them, as it would be the release of those

associated transmitters that were most effected by that disruption.

re-initiating the release of the appropriate neurotransmitters and

the proper transportation back to where they came from seems

plausible for a recovery.

>

> One question I'm not sure about. Does pssd oversensitize the

serotonin

> neurotransmitors, or make them less sensitive. I have been

suffering

> from symptoms of low serotonin, eg. irritable bowel syndrome, mood

> swings, depression etc. I have been taking 5HTP a bit, and it

seemed to

> normalize my sex drive a bit. It also helpde with smooth msucles,

> sensitivity etc.

>

> I would like to know what happens on a mixture of a dopamine

agonist,

> some 5HTP, and maybe something to raise adrenaline and a bit of

> exercise?

>

> Still not sure I really understand the whole thing about serts?

>