Re: vitamin b3 histamine tryptophan link

[Guest guest]

No kidding. I've mentioned this flushing effect. I recommend B3

(Niacin) either alone or in conjunction with sauna treatment. I tried

it for a month - at 150mg I had a fairly profound flush...my whole

body would turn red and there was some mild itching. I reduced to

75mg and I still had the flush but much milder.

It's actually good to get the flush - it means blood vessels are

expanding, thus allowing toxins to pass through the bloodstream,

that's what I've read anyway.

I did not notice any changes during treatment but afterwards my

energy level increased noticeably and this improvement has held. I

can stay up later at night and I sleep much better and deeper. I plan

on doing another course in a month or so.

In my opinion, trying Niacin is a no brainer. Just be careful and

start with a low dose. There's only so much " flushing " one can handle.

Luther

>

> just reading about vitamin b3 in the link below it says that b3

will

> cause you to flush when taken in a high enough amount, but taken

> continuously at high amounts this effect wears off because the

> flushing effects are down to the releace of histamine from cells.

>

> i remember reading research on erectile dysfunction and histamine

> having a positive effect on it, i know that tagamet a h2 blocker

can

> cause erectile dysfunction.

>

> i remeber shay saying his neurotransmitter test had high histamine.

>

> bicker is also taking b3 in the infra red sauna treatment. i.e hes

> been reducing his histamine levels by taking it.

>

> another interesting thing about vitamin b3 is its relationship with

> tryptophan, b3 can be made by the body through the biosynthesis of

> tryptophan. apparently a b3 deficiency can occur if there is a

> deficiency of b1, b2, or b6. as all these vitamins are needed for

the

> processing of tryptophan into b3.

>

> http://www.diagnose-me.com/treat/T120793.html

>

[Guest guest]

i got my niacin today its 500mg pills though, i also have bought a

sauna to use at home while i try this out.

ive got some reservation though mainly because of my gilberts

syndrome and im not really supposed to take b3 supplements because of

its effects on elevating bilirubin, it also has this effect on people

without gilberts syndrome just not in the same ammount.

the other reservation ive got is what ive read about histamine and

erections, i think it actually has a positive effect and after

reading that taking b3 can deplete your body of histamine, well its

something im a bit paranoid about but i have to weigh up the risks

and the benefits i suppose but bickers recovery tells me its at least

worth a go.

have you seen any improvments with pssd while you been doing this

flush thing?

> >

> > just reading about vitamin b3 in the link below it says that b3

> will

> > cause you to flush when taken in a high enough amount, but taken

> > continuously at high amounts this effect wears off because the

> > flushing effects are down to the releace of histamine from cells.

> >

> > i remember reading research on erectile dysfunction and histamine

> > having a positive effect on it, i know that tagamet a h2 blocker

> can

> > cause erectile dysfunction.

> >

> > i remeber shay saying his neurotransmitter test had high

histamine.

> >

> > bicker is also taking b3 in the infra red sauna treatment. i.e

hes

> > been reducing his histamine levels by taking it.

> >

> > another interesting thing about vitamin b3 is its relationship

with

> > tryptophan, b3 can be made by the body through the biosynthesis

of

> > tryptophan. apparently a b3 deficiency can occur if there is a

> > deficiency of b1, b2, or b6. as all these vitamins are needed for

> the

> > processing of tryptophan into b3.

> >

> > http://www.diagnose-me.com/treat/T120793.html

> >

>

[Guest guest]

I would start with a much lower dose than 500mg. I have 300mg pills,

and I cut them into quarters.

Like I said, I did not see improvement during treatment, but I did

see noticeable improvements in energy level and sleep patterns

afterwards. I had a few days where my sexual function improved, but I

reverted back to baseline eventually. Perhaps I didn't stay on

treatment long enough.

Also of note - there were days during treatment where I would wake up

and I had that " drugged " feeling that I had while I was on Celexa. I

took this as a good sign...maybe the drug " escaped " from fat tissue

and passed through the bloodstream. Just a theory.

Luther

> > >

> > > just reading about vitamin b3 in the link below it says that b3

> > will

> > > cause you to flush when taken in a high enough amount, but

taken

> > > continuously at high amounts this effect wears off because the

> > > flushing effects are down to the releace of histamine from

cells.

> > >

> > > i remember reading research on erectile dysfunction and

histamine

> > > having a positive effect on it, i know that tagamet a h2

blocker

> > can

> > > cause erectile dysfunction.

> > >

> > > i remeber shay saying his neurotransmitter test had high

> histamine.

> > >

> > > bicker is also taking b3 in the infra red sauna treatment. i.e

> hes

> > > been reducing his histamine levels by taking it.

> > >

> > > another interesting thing about vitamin b3 is its relationship

> with

> > > tryptophan, b3 can be made by the body through the biosynthesis

> of

> > > tryptophan. apparently a b3 deficiency can occur if there is a

> > > deficiency of b1, b2, or b6. as all these vitamins are needed

for

> > the

> > > processing of tryptophan into b3.

> > >

> > > http://www.diagnose-me.com/treat/T120793.html

> > >

> >

>

[Guest guest]

perhaps it was liberating some of the ssris compound from fat cells,

im going to try and find out some information on histamines

involvement in erections.

if the flush is caused by histamine release and doing it often

depleted histamine from the body then this could have a negative

impact on erections but i suppose you could take the amino acids

histidine to replenish it and carry on doing the flush for prolonged

periods.

histadine is a precursor to histamine.

http://en.wikipedia.org/wiki/Histidine

but i suppose histamine has an inflammatory action and depleting it

may help recovery of tissues, possibly in the genitals and this is

also why things get worce for a while.

i was reading a while ago about prostatitis (inflammation of the

prostate) and there was some similarity's between pssd and that

condition, when i look into it apparently prostatic stones can form

in the prostate just like the stones that can form in the kidneys,

most people with these stones have got prostatis, but there are also

people that have them that havent so they dont associate the stone as

the cause of prostatitis. but the one thing they fail to mention is

the possibility of the individuals reaction to them i.e. an immune or

allergic response to the formation of the stones.

reading more into these stones that form i learnt they were mainly

made up from urea, indicating some sort of back surge of urea into

the prostate to form the stones, if any of us with pssd has got these

stones its likely that while we were on ssris with our urine being

the main way you expel the compound from your body, stones could have

or partly formed out of the actual ssri its self leading to a

possible inflammatory response and possibly pssd in some cases.

http://www.prostatitis.org/stones.html

> > > >

> > > > just reading about vitamin b3 in the link below it says that

b3

> > > will

> > > > cause you to flush when taken in a high enough amount, but

> taken

> > > > continuously at high amounts this effect wears off because

the

> > > > flushing effects are down to the releace of histamine from

> cells.

> > > >

> > > > i remember reading research on erectile dysfunction and

> histamine

> > > > having a positive effect on it, i know that tagamet a h2

> blocker

> > > can

> > > > cause erectile dysfunction.

> > > >

> > > > i remeber shay saying his neurotransmitter test had high

> > histamine.

> > > >

> > > > bicker is also taking b3 in the infra red sauna treatment.

i.e

> > hes

> > > > been reducing his histamine levels by taking it.

> > > >

> > > > another interesting thing about vitamin b3 is its

relationship

> > with

> > > > tryptophan, b3 can be made by the body through the

biosynthesis

> > of

> > > > tryptophan. apparently a b3 deficiency can occur if there is

a

> > > > deficiency of b1, b2, or b6. as all these vitamins are needed

> for

> > > the

> > > > processing of tryptophan into b3.

> > > >

> > > > http://www.diagnose-me.com/treat/T120793.html

> > > >

> > >

> >

>

[Guest guest]

ive found the link to the research on histamines involvement in

erections and i was rite it seem to have a positive effect on

erections.

http://www.ihop-net.org/UniPub/iHOP/pm/162360.html?pmid=7850330

this is weired if the actions of vit b3 is to release histamine and

taken constantly the release of histamine depletes, how can this be

having a positive effect?

i will say this though i started to take the bioflavonoid quercetin

and this apparently stops histamine form being liberated.

i did find it easier to get an erection while i was taking this.

which its contradictory to the research above, but not to the

experiences of bicker, i wonder if histamine has neurotransmitter

activity that is anti erections, as the research was on histamines

direct effects on the penile tissues.

maybe getting histamine down to a level where it doesn't interrupt

mental response is whats happening, thats if histamine has

neurotransmitter activity of a negative kind on erections.

> > > > >

> > > > > just reading about vitamin b3 in the link below it says

that

> b3

> > > > will

> > > > > cause you to flush when taken in a high enough amount, but

> > taken

> > > > > continuously at high amounts this effect wears off because

> the

> > > > > flushing effects are down to the releace of histamine from

> > cells.

> > > > >

> > > > > i remember reading research on erectile dysfunction and

> > histamine

> > > > > having a positive effect on it, i know that tagamet a h2

> > blocker

> > > > can

> > > > > cause erectile dysfunction.

> > > > >

> > > > > i remeber shay saying his neurotransmitter test had high

> > > histamine.

> > > > >

> > > > > bicker is also taking b3 in the infra red sauna treatment.

> i.e

> > > hes

> > > > > been reducing his histamine levels by taking it.

> > > > >

> > > > > another interesting thing about vitamin b3 is its

> relationship

> > > with

> > > > > tryptophan, b3 can be made by the body through the

> biosynthesis

> > > of

> > > > > tryptophan. apparently a b3 deficiency can occur if there

is

> a

> > > > > deficiency of b1, b2, or b6. as all these vitamins are

needed

> > for

> > > > the

> > > > > processing of tryptophan into b3.

> > > > >

> > > > > http://www.diagnose-me.com/treat/T120793.html

> > > > >

> > > >

> > >

> >

>

[Guest guest]

just reading wiki and yes histamine has effects on the brain and also

effects on sleep regulation and on orgasm's.

this could be explaining some of the effects in this sauna treatment

& b3.

" It has been shown that histaminergic cells have the most

wakefulness-related firing pattern of any neuronal type thus far

recorded "

" They fire rapidly during waking, fire more slowly during periods of

relaxation/tiredness and completely stop firing during REM and NREM

(non-REM) sleep. "

could this have something to do with, the positive effects of sleep

deprivation? and the sauna vit b3 treatment? (i think sooooo)

ive mentioned before that pssd could be an increased state of

alertness, taking b3 in high doses is decreasing histamine levels in

the body. (possibly enabling sexual thoughts to have normal reaction)

" Research has shown that histamine is released as part of the human

orgasm from mast cells in the genitals. If this response is lacking

this may be a sign of histapenia (histamine deficiency). In such

cases, a doctor may prescribe diet supplements with folic acid and

niacin (which used in conjunction can increase blood histamine levels

and histamine release), or L-histidine. Conversely, men with high

histamine levels may suffer from premature ejaculations. "

hmmmmm premature ejaculation, thats opposite pssd. (and i see that

they recommend niacin thats b3 yeah. is this a coincidence? i dont

think sooooo)

" H3 receptor activation, which is the reduction of serotonin,

norepinephrine, dopamine, GABA, and acetylcholine. "

(so two much histamine in one place and not in others may be the

cause of pssd?)

http://en.wikipedia.org/wiki/Histamine

p.s people with gilberts have strange things going on with histamine!

(possibly giving more credibility to my genetic theory)

http://www.gilbertssyndrome.com/allergies.php

> > > > > >

> > > > > > just reading about vitamin b3 in the link below it says

> that

> > b3

> > > > > will

> > > > > > cause you to flush when taken in a high enough amount,

but

> > > taken

> > > > > > continuously at high amounts this effect wears off

because

> > the

> > > > > > flushing effects are down to the releace of histamine

from

> > > cells.

> > > > > >

> > > > > > i remember reading research on erectile dysfunction and

> > > histamine

> > > > > > having a positive effect on it, i know that tagamet a h2

> > > blocker

> > > > > can

> > > > > > cause erectile dysfunction.

> > > > > >

> > > > > > i remeber shay saying his neurotransmitter test had high

> > > > histamine.

> > > > > >

> > > > > > bicker is also taking b3 in the infra red sauna

treatment.

> > i.e

> > > > hes

> > > > > > been reducing his histamine levels by taking it.

> > > > > >

> > > > > > another interesting thing about vitamin b3 is its

> > relationship

> > > > with

> > > > > > tryptophan, b3 can be made by the body through the

> > biosynthesis

> > > > of

> > > > > > tryptophan. apparently a b3 deficiency can occur if there

> is

> > a

> > > > > > deficiency of b1, b2, or b6. as all these vitamins are

> needed

> > > for

> > > > > the

> > > > > > processing of tryptophan into b3.

> > > > > >

> > > > > > http://www.diagnose-me.com/treat/T120793.html

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

after reading a bit more about this it seems that a deficiency of

mast cell histamine in the genitals could cause delayed ejaculation

and possibly problems with orgasm.

non mast cell hisamine is in the brain where it acts as

nurotransmiter, " histaminergic cells have the most wakefulness-

related firing pattern of any neuronal type " it seems an excess of

this kind of histamine could possibly give an increased sense of

alertness and possibly the inability to switch to an aroused state of

mind.

> > > > > > >

> > > > > > > just reading about vitamin b3 in the link below it says

> > that

> > > b3

> > > > > > will

> > > > > > > cause you to flush when taken in a high enough amount,

> but

> > > > taken

> > > > > > > continuously at high amounts this effect wears off

> because

> > > the

> > > > > > > flushing effects are down to the releace of histamine

> from

> > > > cells.

> > > > > > >

> > > > > > > i remember reading research on erectile dysfunction and

> > > > histamine

> > > > > > > having a positive effect on it, i know that tagamet a

h2

> > > > blocker

> > > > > > can

> > > > > > > cause erectile dysfunction.

> > > > > > >

> > > > > > > i remeber shay saying his neurotransmitter test had

high

> > > > > histamine.

> > > > > > >

> > > > > > > bicker is also taking b3 in the infra red sauna

> treatment.

> > > i.e

> > > > > hes

> > > > > > > been reducing his histamine levels by taking it.

> > > > > > >

> > > > > > > another interesting thing about vitamin b3 is its

> > > relationship

> > > > > with

> > > > > > > tryptophan, b3 can be made by the body through the

> > > biosynthesis

> > > > > of

> > > > > > > tryptophan. apparently a b3 deficiency can occur if

there

> > is

> > > a

> > > > > > > deficiency of b1, b2, or b6. as all these vitamins are

> > needed

> > > > for

> > > > > > the

> > > > > > > processing of tryptophan into b3.

> > > > > > >

> > > > > > > http://www.diagnose-me.com/treat/T120793.html

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

just done my first sauna treatment and guess what, i had no flushing

effects from the niacin.

i got the 500mg tablets but broke this in half so only took 250mg, i

also drank a couple of pints of water before the sauna, i waited to

see if i got any flushing effects before i got in the sauna. (but

didn't)

did i do something wrong?

i will take the full 500mg tomorrow and see if that works.

[Guest guest]

it says i this article that " recent studies have shown that the

fluorinated antidepressant medications remain in the brain for

prolonged periods after discontinuing the medication "

http://archive.newsmax.com/archives/articles/2007/4/19/194210.shtml?s=lh

it is fluoride, like whats in your tooth past rite?

[Guest guest]

no way check this shit out look no further as to why these things are

so bad, apparently the Nazis planned to put fluoride in the drinking

water to dumb down the population and make them subservient, they

gave it to p.o.w's during the war for this reason!

check out all this shit about flouride/fluorine its in most of the

ssri's and most other pharmaceuticals and there developing thousands

more of them rite now.

http://www.whale.to/a/fluoride23.html

http://naturalhealthnews.blogspot.com/2007/11/bad-fluoride.html

http://www.relfe.com/07/fluoride_drug_dangers.html

http://www.antidepressantsfacts.com/2003-08-Prozac-Paxil-

Fluorophenyl.htm

http://www.fluoridealert.org/health/thyroid/

http://www.fluoridealert.org/health/brain/

http://www.fluoridation.com/brain.htm

http://members.aol.com/doewatch/f.html

http://www.litalee.com/shopexd.asp?id=176 & bc=no

http://www.rense.com/general3/fluo.htm

http://www.slweb.org/ftrcfluorinatedpharm.html

http://www.youtube.com/watch?v=UE2GdUAgyJo & feature=related

http://www.fluoride-journal.com/00-33-1/331-17.pdf

is it any wonder we are fucked when there putting this kind of shit

in drugs!!!!!

>

> it says i this article that " recent studies have shown that the

> fluorinated antidepressant medications remain in the brain for

> prolonged periods after discontinuing the medication "

>

> http://archive.newsmax.com/archives/articles/2007/4/19/194210.shtml?

s=lh

>

>

> it is fluoride, like whats in your tooth past rite?

>

[Guest guest]

I just popped a 1000mg tab and got the flushing.

You took a much lower dose, maybe that's why you didn't get the flushing.

>

> just done my first sauna treatment and guess what, i had no flushing

> effects from the niacin.

>

> i got the 500mg tablets but broke this in half so only took 250mg, i

> also drank a couple of pints of water before the sauna, i waited to

> see if i got any flushing effects before i got in the sauna. (but

> didn't)

>

> did i do something wrong?

>

> i will take the full 500mg tomorrow and see if that works.

>

[Guest guest]

That would be prozac and paxil. They have a flouride molecule bonded

to the chemical structure. As far as I know, some of the drug is

metabolized in the brain and some flouride gets left behind.

It's the same as putting poison in your brain.

So, you're not poisoning yourself with toothpaste becuase it has

regular flouride. Not a chemical alteration that crosses the blood

brain barrier.

>

> it says i this article that " recent studies have shown that the

> fluorinated antidepressant medications remain in the brain for

> prolonged periods after discontinuing the medication "

>

> http://archive.newsmax.com/archives/articles/2007/4/19/194210.shtml?s=lh

>

>

> it is fluoride, like whats in your tooth past rite?

>

[Guest guest]

I get the flushing at just 75mg. So I guess, like other supplements,

we all react differently. Better to start low and work your way up.

Luther

> >

> > just done my first sauna treatment and guess what, i had no

flushing

> > effects from the niacin.

> >

> > i got the 500mg tablets but broke this in half so only took

250mg, i

> > also drank a couple of pints of water before the sauna, i waited

to

> > see if i got any flushing effects before i got in the sauna. (but

> > didn't)

> >

> > did i do something wrong?

> >

> > i will take the full 500mg tomorrow and see if that works.

> >

>

[Guest guest]

here read this link about chelation and iodine, apparently fluoride

can accumulate in the thyroid if theres a low iodine in your system.

taking iodine increases expulsion of fluoride, this could be new ssri

detox treatment.

i wonder if edta and dmsa have any binding affinity for fluoride, if

so that would be a really effective way of getting this shit out out

of out body's once and for all, if its still in there in some form.

http://www.alkalizeforhealth.net/Liodine2.htm

> >

> > it says i this article that " recent studies have shown that the

> > fluorinated antidepressant medications remain in the brain for

> > prolonged periods after discontinuing the medication "

> >

> >

http://archive.newsmax.com/archives/articles/2007/4/19/194210.shtml?

s=lh

> >

> >

> > it is fluoride, like whats in your tooth past rite?

> >

>

[Guest guest]

ill try that tomorrow..how long it take for the flushing effects?

> >

> > just done my first sauna treatment and guess what, i had no

flushing

> > effects from the niacin.

> >

> > i got the 500mg tablets but broke this in half so only took

250mg, i

> > also drank a couple of pints of water before the sauna, i waited

to

> > see if i got any flushing effects before i got in the sauna. (but

> > didn't)

> >

> > did i do something wrong?

> >

> > i will take the full 500mg tomorrow and see if that works.

> >

>

[Guest guest]

you know what ive just read that vitamin c will stop the flushing

effect, ive been taking it with fresh orange juice.

maybe this is the reason why im only getting a flushing effect thats

long lasting and takes ages to happen.

> > >

> > > just done my first sauna treatment and guess what, i had no

> flushing

> > > effects from the niacin.

> > >

> > > i got the 500mg tablets but broke this in half so only took

> 250mg, i

> > > also drank a couple of pints of water before the sauna, i

waited

> to

> > > see if i got any flushing effects before i got in the sauna.

(but

> > > didn't)

> > >

> > > did i do something wrong?

> > >

> > > i will take the full 500mg tomorrow and see if that works.

> > >

> >

>

[Guest guest]

The flushing efect happens in 10 or 20 mins.

It isrecommended to start with a low dose and gradually increase it.

I personally decided to get the 1000mg caps because the price was

better. And I am usually to impatient to take things slowly.

The first time I did it, the firey itching flush was almost unbearable

for a few minutes, but it didn't last long. On repeated doses the

flush isn't as strong. 2morrow I'll try 2000mg.

I take it with folic acid and L-Tyrosine.

My next trial is going to be inosine with Lion's Mane and ghrp-6.

> > >

> > > just done my first sauna treatment and guess what, i had no

> flushing

> > > effects from the niacin.

> > >

> > > i got the 500mg tablets but broke this in half so only took

> 250mg, i

> > > also drank a couple of pints of water before the sauna, i waited

> to

> > > see if i got any flushing effects before i got in the sauna. (but

> > > didn't)

> > >

> > > did i do something wrong?

> > >

> > > i will take the full 500mg tomorrow and see if that works.

> > >

> >

>

[Guest guest]

I've been reading about vitamin C. It's a lot more interesting than I

ever thought it was. There isn't a toxic amount. You can take all the

vit-C you want. I wonder what effect it would have if you took high

dose vit-C with a high dose of B3 ?

> > > >

> > > > just done my first sauna treatment and guess what, i had no

> > flushing

> > > > effects from the niacin.

> > > >

> > > > i got the 500mg tablets but broke this in half so only took

> > 250mg, i

> > > > also drank a couple of pints of water before the sauna, i

> waited

> > to

> > > > see if i got any flushing effects before i got in the sauna.

> (but

> > > > didn't)

> > > >

> > > > did i do something wrong?

> > > >

> > > > i will take the full 500mg tomorrow and see if that works.

> > > >

> > >

> >

>

[Guest guest]

ive read that you can take 3000mg per day of vitamin c as it only is

in the body for about 6hrs, also at a high enough dose it can kill

cancer cells.

taking high dose vit c with b3 would disrupt niacin's effects on

histamine releace.

p.s. i took 500mg of niacin today before the sauna, still no real

great flushing action.

i think the slight flushing effect iis more to do with the sauna than

the niacin. maybe i dont have any histamine to release.

> > > > >

> > > > > just done my first sauna treatment and guess what, i had no

> > > flushing

> > > > > effects from the niacin.

> > > > >

> > > > > i got the 500mg tablets but broke this in half so only took

> > > 250mg, i

> > > > > also drank a couple of pints of water before the sauna, i

> > waited

> > > to

> > > > > see if i got any flushing effects before i got in the

sauna.

> > (but

> > > > > didn't)

> > > > >

> > > > > did i do something wrong?

> > > > >

> > > > > i will take the full 500mg tomorrow and see if that works.

> > > > >

> > > >

> > >

> >

>

[Guest guest]

i think it might be a good idea to take b complex with it also as

they use each other.

> > > >

> > > > just done my first sauna treatment and guess what, i had no

> > flushing

> > > > effects from the niacin.

> > > >

> > > > i got the 500mg tablets but broke this in half so only took

> > 250mg, i

> > > > also drank a couple of pints of water before the sauna, i

waited

> > to

> > > > see if i got any flushing effects before i got in the sauna.

(but

> > > > didn't)

> > > >

> > > > did i do something wrong?

> > > >

> > > > i will take the full 500mg tomorrow and see if that works.

> > > >

> > >

> >

>

[Guest guest]

ive started this so we can discuss and research the organofluorines

that are in the ssris.

ive come across some information about there being a possible link to

the increase in juvenile diabetes and organofluorines in antibiotics.

apparently the suspicion is it having an effect on displacing and

replacing zinc in the pancreas. (im thinking prostate!)

ive also come across information about fluorine accumulating in the

brain long after discontinuing a drug.

and fluorine accumulating in the thyroid if the thyroid was deficient

in iodine.

it look like this shit could have effects on all hormone producing

glands.

http://groups.google.com/group/rec.games.go/msg/c419855058247cd9

i was wondering if chelating agents like edta or dmsa could have the

ability to bind and remove this kind of fluoride, if so it would be a

new detox remedy to try out.

[Guest guest]

"i have asked about this before but didnt get any responses. can

somebody please explain what gaba is and its theoretical connection to

pssd."GABA is a neurotransmitter which regulates 'neuronal excitability'. Which is a pretty fundamental function and basically means it allows or disallows neurons to be activated and stimulated. It has a lot to do with the central nervous system. Benzos modulate the GABA receptor to slow the CNS down. I don't know exactly how it's related to PSSD, but a lot of the posts on here give the impression benzos make things worse for PSSD, Zants' being the strongest example. My gut tells me it's a bad idea. However if you ever plan to come off them I say you do it slowly and carefully, because from memory of the posts cold turkey is not a good idea.Take all of the science with a grain of salt, it's recently acquired Wiki knowledge so I'm not exactly assured of its' veracity.

>

> i have asked about this before but didnt get any responses. can somebody please explain what gaba is and its theoretical connection to pssd. i know that benzos affect gaba and am concerned that they may hinder recovery or make things worse. i have been taking them for quite a while now.

>

> thanks

>

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[Guest guest]

you must wean off slowly from gaba inhibitors. you can have seizures from going cold turkey depending on dose, how long you've been on etc.

I'm a pain and spasticity nurse and deal with folks that have baclofen going intrathecally and if these folks have an interruption in use , they can die. also lyrica is another gaba inhibitor. linda rn

Re: Re: vitamin b3 histamine tryptophan link

"i have asked about this before but didnt get any responses. can somebody please explain what gaba is and its theoretical connection to pssd."GABA is a neurotransmitter which regulates 'neuronal excitability'. Which is a pretty fundamental function and basically means it allows or disallows neurons to be activated and stimulated. It has a lot to do with the central nervous system. Benzos modulate the GABA receptor to slow the CNS down. I don't know exactly how it's related to PSSD, but a lot of the posts on here give the impression benzos make things worse for PSSD, Zants' being the strongest example. My gut tells me it's a bad idea. However if you ever plan to come off them I say you do it slowly and carefully, because from memory of the posts cold turkey is not a good idea.Take all of the science with a grain of salt, it's recently acquired Wiki knowledge so I'm not exactly assured of its' veracity.

>> i have asked about this before but didnt get any responses. can somebody please explain what gaba is and its theoretical connection to pssd. i know that benzos affect gaba and am concerned that they may hinder recovery or make things worse. i have been taking them for quite a while now.> > thanks>

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